T CELL ABNORMALITIES IN AUTOIMMUNE MRL/1PR

自身免疫 MRL/1PR 中的 T 细胞异常

• 批准号: 3158377
• 负责人: MAN-SUN M SY
• 金额: $ 7.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1988-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3158377
• 关键词: T lymphocyte; antiidiotype antibody; autoimmune disorder; autologous transplantation; cell differentiation; cell population study; clone cells; concanavalin A; discoid lupus erythematosus; disease /disorder model; hybridomas; immunoglobulin idiotypes; laboratory mouse; leukocyte activation /transformation; ligands; mitogens; mixed lymphocyte reaction test; monoclonal antibody; oncogenes

Murine SLE is an appropriate model for human SLE, since most, if not all of the immunological abnormalities fundamental to human SLE can also be readily observe in the murine system. The MHL1pr/1pr mouse is one of the strains that spontaneously develop SLE. In addition, all 1pr/1pr mice develop massive generalized lymph node enlargements as the disease progresses. In these enlarged lymph nodes, more than 90% of the cells are T cells. This project is concerned mainly with the in vitro physiology and immunobiology of the abnormal T cells in 1pr/1pr mice, and the relationship between in vitro T cell abnormalities and development of autoimmunity in vivo. Our research goals are summarized as follows: 1). Characterization of responsiveness of each individual T cell subpopulation in 1pr/1pr mice to receptor driven activation signals or polyclonal activators. 2). Characterization of the consequence of activation in vitro with respect to cell surface phenotypes and their differentiation state. Correlation between in vitro observations and in vivo pathogenesis. 3) Characterization of immune abnormalities in vitro and the establishment of an in vitro model system for the study of differentiation of 1pr/1pr T cells.

小鼠SLE是一种适合于人类SLE的模型，因为大多数情况下