EFFECT OF DIET AND PHYSICAL ACTIVITY ON PEAK BONE MASS

饮食和身体活动对峰值骨量的影响

• 批准号: 3156311
• 负责人: ROBERT Roy RECKER
• 金额: $ 9.74万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3156311
• 关键词: alcoholic beverage consumption; body physical activity; bone density; caffeine; dietary calcium; dietary constituent; dietary proteins; dietary trace element; exercise; female; human subject; longitudinal human study; nutrition related tag; osteoporosis; phosphorus; postmenopause; young adult human (21-34)

Two hundred healthy women between ages 20 and 25 will be recruited from the first year classes in the Creighton University Schools of Medicine, Dentistry and Law. Each will be observed for a period of four years in order to test the hypothesis that calcium intake measurably influences the peak adult bone mass achieved after cessation of growth. The effect of other nutrients such as protein, phosphorus, alcohol and caffeine on this consolidation of bone mass will also be tested along with the effect of various self-chosen levels of physical activity. Dietary evaluations will be made at three-month intervals throughout the study and bone mass measurements by radio-grammetry, single photon absorptiometry and dual photon absorptiometry will be made at six-month intervals. Physical activity will be measured at six-month intervals using an activity monitor worn on the wrist for a seven-day period. We hope to confirm the findings of other studies of increased bone mass occurring after cessation of linear growth and to define the determinants of this increased mass. Thus, we hope to be able to show that peak skeletal mass is influenced by non-genetic factors, amenable to intervention early in life in a manner that can result in higher skeletal mass prior at the time when age-related bone loss begins at about age 40. This could result in greater skeletal mass remaining in old age and could offer protection from the crippling fractures of postmenopausal osteoporosis which afflicts nearly one half of our Caucasian women in their later years.

200名年龄在20岁到25岁之间的健康女性将从 克雷顿大学医学院的一年级班级， 牙科和法律专业。每项观察为期四年。 为了验证钙摄入量可测量地影响人体健康的假设 停止生长后达到的成人骨量峰值。的影响 其他营养素，如蛋白质、磷、酒精和咖啡因 还将测试骨量的固结情况，同时测试 各种自选的体力活动水平。饮食评估将 在整个研究过程中每隔三个月进行一次骨密度检查 放射测量法、单光子吸收法和双光子吸收法测量 每隔六个月进行一次光子吸收测定。物理 将使用活动监视器每六个月测量一次活动 戴在手腕上七天。我们希望能确认调查结果 关于停止线性治疗后骨量增加的其他研究 并定义这一质量增加的决定因素。因此，我们 希望能够证明峰值骨骼质量受 非遗传因素，易于在生命早期以某种方式进行干预 这会导致在与年龄相关的时间段之前骨骼质量更高 骨质流失大约在40岁左右开始。这可能会导致更大的骨骼 大量留存到老年，可以提供保护，使其免受残废 近一半的人患有绝经后骨质疏松症的骨折 我们晚年的高加索女性。