PATHOGENESIS OF AIDS/HIV ASSOCIATED PSORIASIS

严重的爆发性银屑病和/或Reiter综合征可能是早期 HIV感染的皮肤表现，预后不良， 艾滋病的发展-获得性免疫缺陷综合症。 的 银屑病和HIV感染之间的联系表明， 免疫学基础和可能的感染基础， 银屑病的发病机制。 齐多夫定治疗快速清除 银屑病，并提供了一个重要的临床模型，了解 银屑病及其与艾滋病的关系 Akin活检 和HIV+和HIV-银屑病患者的外周血淋巴细胞， 齐多夫定治疗后，将研究免疫细胞 人群、DR抗原和细胞因子表达与HIV感染 使用双免疫过氧化物酶和免疫荧光抗体， 核糖核酸探针和35 S-UTP标记的核糖核酸探针 杂交方法 艾滋病/银屑病中的HLA抗原相关性 对DR、DQ和C基因座cDNA进行Southern印迹分析 probes. 艾滋病合并银屑病与齐多夫定疗效分析 在分子水平上诱导缓解应该会带来更好的结果 银屑病的发病机制，其关联的认识 与艾滋病毒感染，以及更好，更安全的治疗牛皮癣， 将军

Severe explosive psoriasis and/or Reiter's syndrome may be an early cutaneous manifestation of HIV infection with a poor prognosis for development of AIDS - the acquired immunodeficiency syndrome. The association between psoriasis and HIV infection suggests an immunologic basis and possibly an infectious basis for the pathogenesis of psoriasis. Zidovudine therapy rapidly clears psoriasis and offers an important clinical model for understanding psoriasis and its observed association with AIDS. Akin biopsies and peripheral lymphocytes from HIV+ and HIV- psoriatics before and after zidovudine therapy will be studied for immunologic cell populations, DR antigen, and cytokine expression, and HIV infection using double immunoperoxidase and immunofluorescence antibodies, and riboprobes and 35S-UTP labeled riboprobe for in situ hybridization. HLA antigen associations in AIDS/psoriasis will be explored using Southern blotting to DR, DQ, and C locus cDNA probes. Analysis of AIDS associated psoriasis and the zidovudine induced remission at the molecular level should lead to a better understanding of the pathogenesis of psoriasis, its association with HIV infection, and better, safer therapy for psoriasis in general.