课题基金 / 基金详情

CYTOMEGALOVIRUSES AND HUMAN MALIGNANCY

CYTOMEGALOVIRUSES AND HUMAN MALIGNANCY
巨细胞病毒与人类恶性肿瘤
批准号：
3165633
负责人：
Eng-Shang Huang
金额：
$11.05万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
项目状态：
已结题
起止时间：
1979-06-01 至 1987-06-30
来源：
https://reporter.nih.gov/project-details/3165633
关键词：
Betaherpesvirinae HeLa cells Hodgkin's disease Kaposi's sarcoma WI38 cell embryo /fetus tissue /cell culture endonuclease gel electrophoresis genetic manipulation genetic strain genome human tissue immunochemistry oncogenic virus radiotracer reproductive system neoplasm salivary gland neoplasms tissue /cell culture viral carcinogenesis virus DNA virus cytopathogenic effect virus genetics

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中文摘要
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英文摘要
OVERALL OBJECTIVES: The overall objective of this project is to investigate the causal association between human cytomegalovirus (human CMV) and various human malignancies, especially the virus and cell interactions that might bear upon the mechanism of herpes virus oncogenesis. GOALS SET FOR CURRENT YEAR: 1. To continue the effort in the detection of the existence of human CMV DNA genome in various cancer tissues. 2. To establish the recombinant DNA library for various CMV DNA fragments. 3. To continue the effort in searching for CMV DNA which is responsible for viral oncogenesis. 4. To compare the biological characteristics of various CMV strains isolated from tumor and various clinical manifestations.
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HCMV DYSREGULATES ENDOTHELIAL CELL FUNCTIONS
HCMV IN AIDS--DISRUPTION OF CELL CYCLE REGULATION
HCMV IN AIDS--DISRUPTION OF CELL CYCLE REGULATION
HCMV IN AIDS--DISRUPTION OF CELL CYCLE REGULATION
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