MicroSensor: development of a novel and highly scalable platform technology for rapid in situ screening for infection on medical device surfaces.

MicroSensor：开发一种新颖且高度可扩展的平台技术，用于快速原位筛查医疗设备表面的感染。

• 批准号: BB/K010794/1
• 负责人: Curtis Dobson
• 金额: $ 22.68万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK010794%2F1
• 关键词: MicroSensor; development; novel; highly; scalable

Many disposable medical products can be colonised by microbes, leading to severe illness or even death of the patient. Traditionally scientists have tried to find better ways to kill the microbes; however this approach has not fully worked, and may never eradicate the problem. Whilst carrying out BBSRC-funded work on this topic, we utilised methods we had developed to provide an alternative strategy for managing these infections. Our "MicroSensor" approach, involves a minature compartment close to the device surface, producing a strongly visible colour change when infected, thus enabling earlier clinical interventions to prevent serious infection occurring. Here we plan to show the MicroSensor is reliable, that its sensitivity can be controlled, and that it functions when used in a contact lens case or wound dressing, the applications closest to market. Major medical device companies have indicated these data would be required to convince them to co-develop the technology.

许多一次性医疗产品可能会被微生物定殖，导致患者重病甚至死亡。传统上，科学家们试图寻找更好的方法来杀死微生物。然而这种方法并没有完全奏效，并且可能永远无法根除问题。在开展 BBSRC 资助的有关该主题的工作时，我们利用我们开发的方法来提供管理这些感染的替代策略。我们的“微传感器”方法涉及靠近设备表面的微型隔室，在感染时产生强烈可见的颜色变化，从而能够更早地进行临床干预，以防止严重感染的发生。在这里，我们计划展示 MicroSensor 的可靠性，其灵敏度可以控制，并且在隐形眼镜盒或伤口敷料（最接近市场的应用）中使用时可以发挥作用。主要医疗设备公司表示，需要这些数据才能说服他们共同开发该技术。