CHLAMYDIA AND THE PATHOGENESIS OF REITER'S SYNDROME
衣原体和 REITER 综合征的发病机制
基本信息
- 批准号:3162858
- 负责人:
- 金额:$ 14.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-09-30 至 1997-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
An infectious etiology for Reiter's syndrome (RS) has long been
suspected, since this disease has often been observed to follow episodes
of urethritis or dysentery. Although many bacterial species can be
associated with the disease, Chlamydia trachomatis has emerged as a
primary etiologic agent in RS, due largely to its prevalence in the
population. Although this organism is the major sexually-transmitted
bacterium in the industrialized world, many aspects of the natural
history of such infections remain relatively poorly understood; eg, both
epidemiological and clinical features of chlamydial infections suggest
that the organism can persist in a culture-negative state under some
circumstances. Recent work from this laboratory has provided direct
molecular biological evidence for persistent/inapparent chlamydial
infections in all anatomically relevant sites; ie, we demonstrated that
high levels of chlamydial nucleic acids can be demonstrated, via a simple
molecular hybridization screening assay and by polymerase chain reaction
(PCR)-based analysis, in conjunctival samples from trachoma patients and
in standard urethral and cervical swabs, all of which are chlamydia-
negative by standard culture or antibody-based screening assays.
Importantly, we also demonstrated that culture-negative synovial tissues
from RS patients similarly contain high levels of chlamydial RNA and DNA,
while parallel samples from patients with other arthropathies do not.
Further, preliminary evidence indicates that the nucleic acids shown in
either hybridization or PCR assays are derived from viable,
metabolically-active chlamydia. In this application, we describe studies
to assess the prevalence and clinical consequences of inapparent
chlamydial infection of the synovium in patients with/without RS. In
these and related laboratory studies, we address clinical, biochemical,
and molecular biological questions regarding the significance, natural
history, characteristics, mechanisms of pathogenesis, and antibiotic
susceptibility of such inapparent chlamydial infections. We further
propose detailed molecular genetic studies to define the transcriptional
and overall metabolic activity of inapparently-infecting chlamydial
cells, and we describe experiments to investigate one possible mechanism
for the reactivation of inapparent synovial chlamydial infection. These
studies will give new insights for development of effective treatment
programs for RS patients, and they will augment our understanding of an
important but as yet poorly recognized facet of the chlamydial
pathogenesis process.
瑞特氏综合征(RS)的感染病因学研究已久
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ALAN PAUL HUDSON其他文献
ALAN PAUL HUDSON的其他文献
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{{ truncateString('ALAN PAUL HUDSON', 18)}}的其他基金
CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
肺炎衣原体——阿尔茨海默病的病原体
- 批准号:
2901888 - 财政年份:1999
- 资助金额:
$ 14.05万 - 项目类别:
CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
肺炎衣原体——阿尔茨海默病的病原体
- 批准号:
6511143 - 财政年份:1999
- 资助金额:
$ 14.05万 - 项目类别:
CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
肺炎衣原体——阿尔茨海默病的病原体
- 批准号:
6170675 - 财政年份:1999
- 资助金额:
$ 14.05万 - 项目类别:
CHLAMYDIA PNEUMONIAE--A PATHOGEN IN ALZHEIMERS DISEASE
肺炎衣原体——阿尔茨海默病的病原体
- 批准号:
6374003 - 财政年份:1999
- 资助金额:
$ 14.05万 - 项目类别:
BENIGN BLADDER DISEASE AND MITOCHONDRIAL FUNCTION
良性膀胱疾病和线粒体功能
- 批准号:
2444098 - 财政年份:1996
- 资助金额:
$ 14.05万 - 项目类别:
BENIGN BLADDER DISEASE AND MITOCHONDRIAL FUNCTION
良性膀胱疾病和线粒体功能
- 批准号:
2905621 - 财政年份:1996
- 资助金额:
$ 14.05万 - 项目类别:
BENIGN BLADDER DISEASE AND MITOCHONDRIAL FUNCTION
良性膀胱疾病和线粒体功能
- 批准号:
2879006 - 财政年份:1996
- 资助金额:
$ 14.05万 - 项目类别:
BENIGN BLADDER DISEASE AND MITOCHONDRIAL FUNCTION
良性膀胱疾病和线粒体功能
- 批准号:
2713386 - 财政年份:1996
- 资助金额:
$ 14.05万 - 项目类别:
BENIGN BLADDER DISEASE AND MITOCHONDRIAL FUNCTION
良性膀胱疾病和线粒体功能
- 批准号:
2147911 - 财政年份:1996
- 资助金额:
$ 14.05万 - 项目类别:
CHLAMYDIA AND THE PATHOGENESIS OF REITER'S SYNDROME
衣原体和 REITER 综合征的发病机制
- 批准号:
2081883 - 财政年份:1993
- 资助金额:
$ 14.05万 - 项目类别:
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CHLAMYDIA AND THE PATHOGENESIS OF REITER'S SYNDROME
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