STUDIES OF FIBRIN DEPOSITION IN CANCER

本研究计划寻求有关纤维蛋白作用机制的信息(S) 在癌症中沉积。这些信息对于设计 针对这种宿主防御机制的治疗方案。这项建议 重点是加深对以下方面的相对重要性的理解 肿瘤相关促凝血剂和巨噬细胞组织因子 在这个过程中。有四个具体目标： 1.组织因子(Tf)相关抗原的鉴定(Tf：RAG) 其他肿瘤Pca和纤维蛋白在人原位肿瘤中的表达。 2.Tf(和其他Pca)的鉴定和分子特征 分离的人类肿瘤细胞和肿瘤相关的MO。 3.抗兔转铁蛋白单抗的制备及鉴定 4.转铁蛋白特异性单抗体内效应的测定 抗体对MO-Tf表达、纤维蛋白沉积和 兔肿瘤模型中的肿瘤生长。(A)

This research proposal seeks information about the mechanism(s) for fibrin deposition in cancer. Such information is critical for the design of treatment regimens aimed at this host defense mechanism. The proposal focuses on developing an understanding of the relative importance of tumor-associated procoagulants (PCA) and macrophage tissue factor (MO-TF) in this process. There are four specific goals: 1. Identification of antigens related to tissue factor (TF) (TF:RAg), other tumor PCA, and fibrin in human tumors in situ. 2. Identification and molecular characterization of TF (and other PCA) in isolated human tumor cells and tumor-associated MO. 3. Production and characterization of monoclonal antibodies to rabbit TF. 4. Determination of the in vivo effects of TF-specific, monoclonal antibodies on the expression of MO-TF, the deposition of fibrin and tumor growth in a rabbit tumor model. (A)