WHAT DISTINGUISHES WATER IN CANCER AND IN NORMAL TISSUES

癌症和正常组织中的水有什么区别

• 批准号: 3164362
• 负责人: GILBERT N LING
• 金额: $ 15.59万
• 依托单位: PENNSYLVANIA HOSPITAL (PHILADELPHIA)
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-06-01 至 1988-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3164362
• 关键词: adenosine triphosphate; adsorption; biophysics; calorimetry; cell osmotic pressure; cell water; cellular oncology; chemical hydration; electron microscopy; fluidity; ion transport; malignant ascites; membrane model; membrane permeability; molecular polarity; neoplastic cell; nonelectrolyte transport; nuclear magnetic resonance spectroscopy; pentoses; physical property; polymerization; polymers; potassium; relaxation spectrometry; sodium; solute; water solubility

Water makes up from 75 to 85% of all living matter. Thus water is not only the medium in which all biomedical reactions take place, it is also by far the major substance of living matter. For these fundamental reasons, the discovery that water in cancer cells has longer NMR relaxation time (T1 and T2) is of great potential importance. Having established that these longer T1 and T2 are not due to the larger water contents but are distinctly different from all normal host animal tissues but are very similar among all variety of cancer cells of diverse origin, our immediate plan for the next year would encompass both fundamental inquiries of the physico-chemical basis for differences in T1 and T2 of model systems as well as living cells. We will also continue our investigation of the different T1 and T2 of host tissues from cancer-bearing animals particularly in relation to animals bearing "red ascites" and bearing "yellow ascites" with the hope of understanding more about the process of cancer cell dissemination.

水占所有生物的75％至85％。 因此，水不仅是 所有生物医学反应发生的媒介，也是迄今为止的主要 生活物质的实质。 由于这些根本原因，发现 癌细胞中的水具有更长的NMR松弛时间（T1和T2）很棒 潜在的重要性。 确定这些更长的T1和T2不是 由于水含量较大，但与所有正常人明显不同 宿主动物组织，但在所有种类的癌细胞中都非常相似 多样的起源，我们明年的直接计划将涵盖 对T1和T2差异的物理化学基础的基本询问 模型系统和活细胞的。 我们还将继续我们的 研究来自癌症的宿主组织的不同T1和T2 动物，特别是与带有“红腹水”和轴承的动物有关的动物 “黄色腹水”希望更多地了解癌症的过程 细胞传播。