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TRANSFECTION BY ENDOGENOUS HUMAN TRANSFORMING GENES

TRANSFECTION BY ENDOGENOUS HUMAN TRANSFORMING GENES
内源性人类转化基因的转染
批准号：
3168445
负责人：
GEOFFREY M COOPER
金额：
$17.52万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
1981
资助国家：
美国
项目状态：
已结题
起止时间：
1981-05-01 至 1989-04-30
来源：
https://reporter.nih.gov/project-details/3168445
关键词：
B lymphocyte Burkitt's lymphoma DNA antiserum embryo /fetus tissue /cell culture gene expression genetic manipulation genetic mapping genetic recombination human tissue laboratory mouse lymphoma molecular cloning multiple myeloma neoplasm /cancer genetics neoplastic cell neoplastic transformation nucleic acid hybridization nucleic acid sequence radiotracer tissue /cell culture transfection

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英文摘要
The overall goal of the research is the analysis of cellular-transforming genes in human neoplasms. We will focus on the nonvirus-related transforming genes that are activated in human B-lymphocyte neoplasms and detected by transfection of NIH 3T3 cells. These genes will be characterized by molecular cloning and nucleotide sequencing in order to identify their gene products and to determine the molecular alterations responsible for activation of their transforming potential in neoplastic cells. Antisera against predicted gene products will be used for characterization of these transforming proteins. The role of these transforming genes in lymphomagenesis will be investigated by transfection of human B lymphocytes. (X)
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Regulation of apoptosis by PI 3-kinase/Akt signaling
PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
  • 批准号：
    2668576
  • 项目类别：
  • 资助金额：
    $24.14万
  • 财政年份：
    1998
  • 负责人：
    GEOFFREY M COOPER
  • 依托单位：
    BOSTON UNIVERSITY MEDICAL CAMPUS
PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
  • 批准号：
    2378511
  • 项目类别：
  • 资助金额：
    $23.53万
  • 财政年份：
    1996
  • 负责人：
    GEOFFREY M COOPER
  • 依托单位：
    DANA-FARBER CANCER INST
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