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TRANSFECTION BY ENDOGENOUS HUMAN TRANSFORMING GENES

TRANSFECTION BY ENDOGENOUS HUMAN TRANSFORMING GENES
内源性人类转化基因的转染
批准号:
3168444
负责人:
GEOFFREY M COOPER
金额:
$16.72万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1981
资助国家:
美国
项目状态:
已结题
起止时间:
1981-05-01 至 1989-04-30

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中文摘要
翻译
研究的总体目标是对细胞转化的分析 人类肿瘤中的基因。我们将重点关注与病毒无关的 转化人B淋巴细胞肿瘤中激活的基因和 用NIH3T3细胞进行检测。这些基因将是 以分子克隆和核苷酸测序为特征的 鉴定他们的基因产物并确定分子变化 在肿瘤中负责激活它们的转化潜能 细胞。针对预测基因产物的抗血清将用于 这些转化蛋白的特性。这些因素的作用 淋巴肿大中的转化基因将通过转基因进行研究 人类B淋巴细胞。(十)
英文摘要
The overall goal of the research is the analysis of cellular-transforming genes in human neoplasms. We will focus on the nonvirus-related transforming genes that are activated in human B-lymphocyte neoplasms and detected by transfection of NIH 3T3 cells. These genes will be characterized by molecular cloning and nucleotide sequencing in order to identify their gene products and to determine the molecular alterations responsible for activation of their transforming potential in neoplastic cells. Antisera against predicted gene products will be used for characterization of these transforming proteins. The role of these transforming genes in lymphomagenesis will be investigated by transfection of human B lymphocytes. (X)
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Regulation of apoptosis by PI 3-kinase/Akt signaling
PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
  • 批准号:
    2668576
  • 项目类别:
  • 资助金额:
    $24.14万
  • 财政年份:
    1998
  • 负责人:
    GEOFFREY M COOPER
  • 依托单位:
PROTO-ONCOGENES IN GAMETOGENESIS AND EARLY DEVELOPMENT
  • 批准号:
    2378511
  • 项目类别:
  • 资助金额:
    $23.53万
  • 财政年份:
    1996
  • 负责人:
    GEOFFREY M COOPER
  • 依托单位:
海外基金