课题基金 / 基金详情

CYTOTOXIC MACROCYCLES CYTOCHALASIN PYRROLIZIDINE ANALOGS

CYTOTOXIC MACROCYCLES CYTOCHALASIN PYRROLIZIDINE ANALOGS
细胞毒性大环细胞松弛素吡咯利嗪类似物
批准号：
3164806
负责人：
EDWIN VEDEJS
金额：
$21.52万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-07-01 至 1990-12-31
来源：
https://reporter.nih.gov/project-details/3164806
关键词：
Retroviridae Retroviridae disease antineoplastics biological transport cell membrane chelating agents cytochalasins cytotoxicity drug design /synthesis /production drug screening /evaluation leukocyte antigen typing membrane activity monocrotaline neoplasm /cancer pharmacology neoplastic transformation nitrogen compounds sulfur compounds tissue /cell culture virus infection mechanism virus replication

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中文摘要
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英文摘要
The isoindolone fragment of cytochalasin D has been assembled by Diels-Alder reaction of an optically active N-benzoyl pyrrolinone intermediate with a substituted diene. This intermediate will be taken on to analogs of cytochalasin D by a ring expansion sequence where a 6-membered sulfide ring is bridged across the alpha, alpha' positions by a 6-carbon chain. The result of this reaction would be to complete the 11-membered carbocyclic periphery of cytochalasin D.
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