KIDNEY RESPONSE TO FRACTIONATED RADIATION

这个项目的目标是研究肾脏对 分次辐射及其与普通辐射的相互作用 化疗药物。晚期对非增殖组织的损害是一种 放射治疗和联合放射治疗的主要限制因素 化疗正在增加。关于迟交的信息很少。 分次放射治疗对组织的损伤及其影响 药物与辐射在这种组织中的相互作用。特别目标是：1) 研究辐射耐受性的时间依赖性或缺乏时间依赖性 2)研究长间隙和短间隙在治疗中的作用 关于肾脏的辐射耐受性；3)年龄的确定 肾脏对辐射耐受性的依赖性；4)测定 部分肾屏蔽术的保护范围 5)研究慢性给药对小鼠的影响。 化疗药物对肾脏的辐射毒性；6)测定 肾照射对甲氨蝶呤药代动力学的影响。 这些实验将在大鼠身上模拟药物辐射剂量和 人类使用的时间表。因此，辐射和药物将是 对未麻醉的动物分次给药。

The goal of this project is to study the response of the kidney to fractionated radiation and the interaction of this irradiation with common chemotherapeutic agents. Late damage to nonproliferating tissues is a major limiting factor in radiotherapy and the use of combined radiation and chemotherapy is increasing. There is a paucity of information on late tissue damage from fractionated radiotherapy and on the effects of drug-radiation interactions in such tissues. Special Aims are: 1) To study the time-dependence, or the lack thereof, of the radiation tolerance of the kidney; 2) to study the effects of long and short gaps in treatment on the radiation tolerance of the kidney; 3) to determine the age dependence of the radiation tolerance of the kidney; 4) to determine the extent of protection produced by partial kidney shielding during irradiation; 5) to study the effects of chronic administration of common chemotherapeutic agents on the renal toxicity of radiation; 6) to determine the effects of kidney irradiation on the pharmacokinetics of methotrexate. These experiments will simulate in rats the drug-radiation doses and schedules used in man. Radiation and drugs will, therefore, be administered in fractionated doses to unanesthetized animals.