课题基金 / 基金详情

TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS

TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS
阿贝尔森鼠白血病病毒的转化
批准号：
3167668
负责人：
OWEN N. WITTE
金额：
$16.79万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
项目状态：
已结题
起止时间：
1980-05-01 至 1991-04-30
来源：
https://reporter.nih.gov/project-details/3167668
关键词：
Abelson leukemia virus Retroviridae disease chronic leukemia chronic myelogenous leukemia disease /disorder model gene expression genetic manipulation genetic regulation helper virus laboratory mouse laboratory rabbit oncogenic virus protein kinase radiotracer serology /serodiagnosis surface antigens temperature sensitive mutant tissue /cell culture viral leukemogenesis virus RNA virus genetics virus protein

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中文摘要
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英文摘要
This proposal will investigate the molecular mechanisms used by the abl oncogene in its normal and abnormal growth regulation. Comparison of the structures, regulation, hematopoietic transformation activities, and tyrosine kinase enzymatic properties of the murine cellular, and viral forms of the abl gene as well as the translocation derived form of the abl gene found in Chronic Myelogenous Leukemia cells will be performed. Emphasis will be placed on establishing transformed cell models for murine stem cell populations under the regulation of abl or other oncogenes in concert with improved culture techniques. These studies should aid our understanding of the mechanisms of oncogenesis and hematopoietic development.
期刊论文(2)
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会议论文
Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential.
阿贝尔森病毒感染的细胞可以表现出体外生长受限和低致癌潜力。
DOI： 10.1128/jvi.40.2.577-584.1981
发表时间： 1981
期刊： Journal of virology
影响因子： 5.4
作者： [Whitlock,CA, Witte,ON]
通讯作者： Witte,ON
Immunohistochemical and ultrastructural spectrum of hepatic sarcomas of childhood: evidence for a common histogenesis.
儿童肝肉瘤的免疫组织化学和超微结构谱：共同组织发生的证据。
DOI： --
发表时间： 1991
期刊： Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子： --
作者： [Parham,DM, Kelly,DR, Donnelly,WH, Douglass,EC]
通讯作者： Douglass,EC
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