AN EPIDEMIOLOGIC STUDY OF MALE BREAST CANCER

男性乳腺癌的流行病学研究

• 批准号: 3167863
• 负责人: JOHN THOMAS CASAGRANDE
• 金额: $ 8.87万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-08-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3167863
• 关键词: X ray; adult human (21+); alcoholic beverage consumption; blood chemistry; breast neoplasms; cancer risk; diagnostic tests; dietary lipid; drug carcinogenesis; estradiol; hormone related neoplasm /cancer; human population genetics; human subject; interview; liver disorder; male; mouth; neoplasm /cancer genetics; nutrition related tag; obesity; prolactin; questionnaires; radiation carcinogenesis; sex hormones; socioeconomics; testosterone; urinalysis; vital statistics

This document describes a proposal to investigate the relationship between hormone status and development of male breast cancer. Two approaches will be used. The first will be a case-control interview study of 73 "other white" patients under age 75 at diagnosis and 73 such age-matched neighborhood controls. All patients will be obtained from the files of the Los Angeles County/USC Cancer Surveillance Program, from which about 22 such cases under age 75 are identified annually. Data will be obtained by personal interviews conducted by a trained nurse epidemiologist. Questionnaire items will focus on factors known to effect hormone levels including obesity, liver disease and exposure to certain drugs. Data will also be collected on marriage and reproductive history, prior breast disease, family history of breast cancer, diet and other possibly relevant conditions such as radiation. The second approach will be to compare endogenous serum hormone levels in patients, their brothers and controls. Specimens will only be obtained from patients treated by surgery alone and who, at time of specimen collection, have no active disease or other illness. Hormones to be measured include estrone, estradol, testosterone, and prolactin. Sex hormone binding globulin will also be measured. For comparison with previous studies, 12 hour urine samples will be collected and assayed for conjugated estrogen fractions. Buccal smears will be obtained on all individuals and tested for sex-chromatin.

本文件描述了一项调查以下关系的提案 激素状态和男性乳腺癌的发展。 两种方法将 被使用。 第一个是对 73 名“其他人”的病例对照访谈研究。 诊断时年龄低于 75 岁的“白人”患者以及 73 名年龄匹配的患者 邻里控制。 所有患者都将从医院的档案中获得 洛杉矶县/南加州大学癌症监测计划，其中约 22 每年都会发现75岁以下的此类病例。 数据将通过以下方式获得 由经过培训的护士流行病学家进行个人访谈。 问卷项目将重点关注已知影响激素水平的因素 包括肥胖、肝病和接触某些药物。 数据会 还收集婚姻和生育史、先前的乳房史 疾病、乳腺癌家族史、饮食和其他可能相关 辐射等条件。 第二种方法是比较 患者、其兄弟和对照的内源性血清激素水平。 样本仅取自仅接受手术治疗的患者，并且 在采集标本时没有活动性疾病或其他疾病的人 疾病。 待测激素包括雌酮、雌二醇、睾酮、 和催乳素。 性激素结合球蛋白也将被测量。 为了 与之前的研究相比，将收集12小时的尿液样本 并测定结合雌激素组分。 颊涂片将会 在所有个体上获得并测试性染色质。