DETECTION OF BLADDER AND KIDNEY TUMORS BY CELL MIGRATION

我们最近发现移行细胞癌患者的尿液 膀胱癌和肾细胞癌刺激显著 毛细血管和内皮Balb 3T3细胞的迁移大于尿液 从正常人、良性疾病患者或 切除了肿瘤的人 我们的目的是进一步调查这一点 现象，并确定尿液中的这种特性是否可用于检测 新的和复发的膀胱和肾脏肿瘤。 我们计划确定 这些因素扰乱了细胞迁移的水平， 使测定标准化。 我们还将此测定与尿 细胞学，以确定潜在的有用性，作为一个筛选试验，在高 风险患者。 我们计划进一步表征并开始纯化 尿液中的物质负责这一观察，因为长期 本工作的目的是开发一种新的，非侵入性的膀胱检查方法 和肾肿瘤的治疗方法。 这样的测试 将导致更好地管理这些疾病的患者。

We have recently found that urine from patients with transitional cell carcinoma of the bladder and renal cell carcinoma stimulate significantly greater migration of capillary and endothelial Balb 3T3 cells than urine from either normal individuals, patients with benign diseases or patients who have had their tumors removed. Our aim is to further investigate this phenomenon and determine if this property in urine can be used to detect new and recurrent bladder and kidney tumors. We plan to determine what factors upset the level of cell migration and what can be done to standardize the assay. We will also compare this assay with urinary cytology to determine the potential usefulness as a screening test in high risk patients. We plan to further characterize and begin to purify the substance in urine responsible for this observation, because the long term objective of this work is to develop a new, noninvasive test for bladder and kidney tumors that can be used on a widespread basis. Such a test would result in better management of patients with these diseases.