DETECTION OF BLADDER AND KIDNEY TUMORS BY CELL MIGRATION

通过细胞迁移检测膀胱和肾脏肿瘤

• 批准号: 3171086
• 负责人: GERALD W CHODAK
• 金额: $ 13.94万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-03-01 至 1986-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3171086
• 关键词: bioassay; bladder neoplasm; cell migration; cytodiagnosis; high performance liquid chromatography; human subject; kidney neoplasms; metastasis; neoplasm /cancer diagnosis; neoplasm /cancer relapse /recurrence; tissue /cell culture; transitional cell carcinoma; urinalysis; vascular endothelium

We have recently found that urine from patients with transitional cell carcinoma of the bladder and renal cell carcinoma stimulate significantly greater migration of capillary and endothelial Balb 3T3 cells than urine from either normal individuals, patients with benign diseases or patients who have had their tumors removed. Our aim is to further investigate this phenomenon and determine if this property in urine can be used to detect new and recurrent bladder and kidney tumors. We plan to determine what factors upset the level of cell migration and what can be done to standardize the assay. We will also compare this assay with urinary cytology to determine the potential usefulness as a screening test in high risk patients. We plan to further characterize and begin to purify the substance in urine responsible for this observation, because the long term objective of this work is to develop a new, noninvasive test for bladder and kidney tumors that can be used on a widespread basis. Such a test would result in better management of patients with these diseases.

我们最近发现患者尿液中有移行细胞

项目成果

Presence of heparin binding growth factor in mouse bladder tumors and urine from mice with bladder cancer.

小鼠膀胱肿瘤和膀胱癌小鼠尿液中存在肝素结合生长因子。

• 发表时间: 1986
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Chodak,GW;Shing,Y;Borge,M;Judge,SM;Klagsbrun,M
• 通讯作者: Klagsbrun,M