APPRAISAL OF INTERVENTIONS--PROSTATE CARCINOMA

描述(申请人的描述)：前列腺癌是最常见的 诊断为男性实体瘤。尽管在早期检测方面有所改进，但许多 患者的进展是基于血清前列腺特异性抗原的升高。 传统疗法可能会减缓病情进展，但很少能治愈晚期或 进行性疾病。为了改善结果，许多男性寻求替代或 他们从业馀媒体那里了解到的非常规方法， 互联网和其他非医疗来源。因为干预是在外面 主流医学，很少有医生意识到这些选择，也没有准备好 为病人提供咨询服务。因为人们对替代能源的兴趣与日俱增 医学，一个为患者和医生举行的会议，他们对 非常规战略既是必要的，也是及时的。这样做的目的是 会议的目的是(1)对现有数据进行批判性评估 非常规替代战略的潜在影响 泛指恶性或特指前列腺癌，(2)好转 医生对现有替代干预措施的认识，以便 医生能够为他们的病人提供咨询，个人可以决定 是否纳入干预措施，以及(3)确定潜在飞行员 学习和其他研究机会，这将进一步了解 非常规干预的潜在价值。这将是 通过对14个主题中的每个主题进行15分钟的演示来完成 干预措施可分为饮食、食品补充剂和提取物， 维生素、矿物质、草药和动物提取物。在每一次演讲之后， 主持人将直接向演讲者提问，以批判性地评价 为了给观众留下三个问题的答案： (1)现有信息是否支持现在纳入干预措施 正在等待更明确的科学研究，如果不是，(2)是 具有足够挑衅性的信息，应启动试点研究 患者是否应该积极登记，或者(3)信息如此有限， 含糊的，或缺乏任何需要进一步基础研究的客观数据 在考虑使用它们之前？来自的书面问题 将以书面形式征集听众，并将其转告演讲者，提供 他们将帮助回答上述问题。每一位演讲者将 向主持人提供他们的演讲，包括轶事案例，以便 最佳问题可以在会议前准备好。

DESCRIPTION (Applicant's Description): Prostate cancer is the most commonly diagnosed solid tumor in men. Despite improvements in early detection, many patients progress based on a rising serum prostate specific antigen. Conventional therapies may slow progression but rarely cure advanced or progressive disease. To improve outcome, many men look to alternative or unconventional approaches which they learn about from the lay press, the internet and other non medical sources. Since the interventions are outside mainstream medicine, few physicians are aware of these options nor prepared to offer patient counseling. Because of growing interest in alternative medicine, a conference for patients and physicians which critically reviews unconven-tional strategies is both necessary and timely. The goals of this conference are (1) to critically evaluate the existing data supporting the potential impact of unconventional alternative strategies as they relate generally to malignancy or specifically to prostate cancer, (2) to improve awareness among physicians about existing alternative interventions so that physicians are able to counsel their patients and individuals can decide whether to incorporate an intervention, and (3) to identify potential pilot studies and other research opportunities which would further knowledge about the potential value of unconventional interventions. This will be accomplished by a 15 minute presentation on each of 14 topics involving interventions which can be divided into diet, food supplements and extracts, vitamins, minerals, herbs and animal extracts. Following each talk, a moderator will direct questions to the speaker to critically appraise the topic in order to leave the audience with the answers to three questions: (1) does the existing information support incorporating an intervention now while awaiting more definitive scientific studies, and if not, (2) is the information sufficiently provocative that pilot studies should be initiated and should patients actively enroll, or (3) is the information so limited, vague, or lacking any objective data that further basic studies are needed before consideration is given to their use? Written questions from the audience will be solicited in writing and relayed to the speaker providing that they will help answer the above questions. Each of the presenters will provide the moderator with their talk including anecdotal cases so that optimal questions can be prepared before the conference.