PROJECT ON THE TNM CLASSIFICATION OF MALIGNANT TUMORS

恶性肿瘤 TNM 分类项目

• 批准号: 3176281
• 负责人: UMBERTO VERONESI
• 金额: $ 5.41万
• 依托单位: INTERNATIONAL UNION AGAINST CANCER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3176281
• 关键词: gastrointestinal neoplasms; international health /scientific organization; liver neoplasms; lung neoplasms; mesothelioma; metastasis; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer invasiveness; neoplasm /cancer therapy; nervous system carcinoma; prognosis; sarcoma; travel

A long-term aim of the UICC is to attain an internationally acceptable classification of the anatomical extent of cancer (TNM). The UICC is the only international organization responsible for this project, coordinating and leading the several national TNM committees which carry out specific tasks. The relaxation of coordinating efforts over a period of several years led to the development of "double standards", variations in classification criteria among the participating groups. This became such a critical problem that for the past five years (1982 to 1987), all efforts of the UICC TNM Project and its national TNM committees (including the American Joint Committee on Cancer-AJCC) were directed towards unification. The goal was achieved. A single TNM Classification is now in press from both the UICC and the AJCC. This not only unifies, but updates, the component site-specific classifications based on clinical and pathological data. Furthermore, during the process, TNM classifications were elaborated for sites not previously covered. Five specific goals are considered for the next phase of work in this project: -implementation: to disseminate and promote the universal use of the system; 2-monitoring: to measure user satisfaction or otherwise; 3-testing: to determine validity, especially in respect to new diagnostic and imaging modalities; 4- classification of new tumor types: namely mesotheliomas, visceral sarcomas, small bowel and appendiceal carcinomas, gastrointestinal carcinoids and hepatic and pulmonary metastases; -prognostic grading: to develop an integrated system that will combine the data of anatomical extent of disease with other factors, eg. histologic grade, aneuploidy, biochemical markers, age, sex, immunological response, for a more accurate approach to prognosis than given by extent of disease alone. The costs of the above tasks and studies will be borne by the national TNM committees and are not included in this grant proposal. This grant will only cover the costs of coordinating the work, namely five annual TNM Committee meetings and four editorial sessions.

国际商会的一个长期目标是实现国际 癌症解剖学范围的可接受分类 （TNM）。 国际商会是唯一一个 负责该项目，协调和领导几个 执行具体任务的国家TNM委员会。 在一段时间内放松协调努力， 多年来，导致了“双重标准”的发展， 参与团体的分类标准。 这 在过去的五年里（1982年）， 至1987年），UICC TNM项目及其国家 TNM委员会（包括美国联合委员会） 巨蟹座-AJCC）被导向统一。 目的达到了。 现在有一个单一的TNM分类 从UICC和AJCC按下。 这不仅统一了， 但更新，组件站点特定的分类基于 临床和病理数据。 此外，在此过程中， TNM分类是为以前没有的网站制定的 覆盖. 下一阶段的五个具体目标是： 执行：传播和促进 系统的普遍使用; 2-监控：测量用户 满意度或其他; 3-测试：确定有效性， 特别是在新的诊断和成像模式方面; 4- 新肿瘤类型的分类：即间皮瘤， 内脏肉瘤，小肠和阑尾癌， 胃肠道类癌和肝、肺转移; - 预后分级：建立一个综合系统， 联合收割机将疾病的解剖范围数据与其他 因素，例如。组织学分级，非整倍体，生化标记， 年龄、性别、免疫反应，以便更准确地 而不是仅仅根据疾病的程度来判断预后。 的费用 上述任务和研究将由国家技术管理局承担 委员会，不包括在本赠款提案。 这 赠款将只支付协调工作的费用，即 五次TNM委员会年会和四次编辑会议。