PROJECT ON THE TNM CLASSIFICATION OF MALIGNANT TUMORS

恶性肿瘤 TNM 分类项目

• 批准号: 3176275
• 负责人: UMBERTO VERONESI
• 金额: $ 4.35万
• 依托单位: INTERNATIONAL UNION AGAINST CANCER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3176275
• 关键词: gastrointestinal neoplasms; international health /scientific organization; liver neoplasms; lung neoplasms; mesothelioma; metastasis; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer invasiveness; neoplasm /cancer therapy; nervous system carcinoma; prognosis; sarcoma; travel

A long-term aim of the UICC is to attain an internationally acceptable classification of the anatomical extent of cancer (TNM). The UICC is the only international organization responsible for this project, coordinating and leading the several national TNM committees which carry out specific tasks. The relaxation of coordinating efforts over a period of several years led to the development of "double standards", variations in classification criteria among the participating groups. This became such a critical problem that for the past five years (1982 to 1987), all efforts of the UICC TNM Project and its national TNM committees (including the American Joint Committee on Cancer-AJCC) were directed towards unification. The goal was achieved. A single TNM Classification is now in press from both the UICC and the AJCC. This not only unifies, but updates, the component site-specific classifications based on clinical and pathological data. Furthermore, during the process, TNM classifications were elaborated for sites not previously covered. Five specific goals are considered for the next phase of work in this project: -implementation: to disseminate and promote the universal use of the system; 2-monitoring: to measure user satisfaction or otherwise; 3-testing: to determine validity, especially in respect to new diagnostic and imaging modalities; 4- classification of new tumor types: namely mesotheliomas, visceral sarcomas, small bowel and appendiceal carcinomas, gastrointestinal carcinoids and hepatic and pulmonary metastases; -prognostic grading: to develop an integrated system that will combine the data of anatomical extent of disease with other factors, eg. histologic grade, aneuploidy, biochemical markers, age, sex, immunological response, for a more accurate approach to prognosis than given by extent of disease alone. The costs of the above tasks and studies will be borne by the national TNM committees and are not included in this grant proposal. This grant will only cover the costs of coordinating the work, namely five annual TNM Committee meetings and four editorial sessions.

UICC的一个长期目标是实现国际 可接受的癌症解剖范围分类 (TNM)。UICC是唯一的国际组织 负责这个项目，协调和领导几个项目 执行具体任务的国家技术需求管理委员会。 在几年的时间里放松协调努力 多年来，导致了“双重标准”的发展，在 参与组之间的分类标准。这 成为如此严重的问题，以至于在过去五年(1982) 至1987年)，UICC技术监测项目的所有努力及其国家 技术需要管理委员会(包括美洲技术合作联合委员会 癌症-AJCC)朝着统一的方向前进。 目标实现了。单一的TNM分类现已在 来自UICC和AJCC的新闻。这不仅统一了， 但更新后，组件站点特定的分类基于 临床和病理资料。此外，在这个过程中， 详细说明了以前未对站点进行的TNM分类 盖好了。考虑了下一阶段的五个具体目标 本项目的工作：-执行：传播和促进 系统的通用性；2-监控：衡量用户 满意度或其他；3-测试：确定有效性， 特别是在新的诊断和成像模式方面；4- 新的肿瘤类型分类：即间皮瘤， 内脏肉瘤，小肠和阑尾癌， 胃肠道类癌与肝、肺转移； -预测分级：开发一个综合系统，将 将疾病的解剖范围与其他数据相结合 因素，例如。组织学分级，非整倍体，生化标志物， 年龄、性别、免疫反应，以获得更准确的方法 对预后的影响比仅根据疾病的程度给出的结果要好。所需成本 上述任务和研究将由国家TNM承担 委员会，并不包括在这项拨款提案。这 格兰特将只支付协调工作的费用，即 技术需要管理委员会五次年度会议和四次编辑会议。