IN UTERO DES EXPOSURE: CANCER AND MEDICAL ILLNESSES

子宫内暴露：癌症和疾病

• 批准号: 3174464
• 负责人: KENNETH L NOLLER
• 金额: $ 19.97万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-15 至 1989-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3174464
• 关键词: adenocarcinoma; cancer information system; cancer risk; chemical carcinogen; diethylstilbestrol; drug related neoplasm /cancer; embryo /fetus drug adverse effect; longitudinal human study; neoplasm /cancer surgery; patient /disease registry; squamous cell carcinoma

The purpose of this project is to add approximately 22,500 person years for the detection of cancer and other major medical illnesses among the 5,464 women who have previously been enrolled in the DESAD Project. This continued surveillance will enable us to accomplish five specific aims: to determine the magnitude of the excess of squamous neoplasia in exposed over unexposed women and to determine if the increased risk continues over the next five years, to determine if the risk of adenocarcinoma increases during the next five years, to determine the rates of serious medical illnesses in the DES exposed women and to compare these rates with the control groups and published age specific incidence rates for the same diseases, to determine the frequency of abdominal and gynecologic surgery among DES exposed women and to compare these rates with the unexposed controls and the rates available from the National Center for Health Statistics, and to maintain contact with the DESAD Project exposed cohort at minimal expense. These aims will be accomplished by soliciting information by the method of mailed questionnaire. Each participant will be questioned annually concerning the diagnosis of medical diseases or the performance of surgical procedures. Previous experience of the DESAD cohort has indicated that in excess of 90 percent of the women previously enrolled in the project can be expected to comply with the requests for information. The sample size considerations are explained in detail in the project and indicate that it will be possible to detect, with a power of .9, a two-fold difference in the rates of many common medical diseases and surgical procedures at the p=.05 level.

该项目的目的是增加约 22,500 人年 在 5,464 名患者中发现癌症和其他重大疾病 以前参加过 DESAD 项目的女性。 这 持续的监督将使我们能够实现五个具体目标： 确定暴露超过的鳞状瘤形成的过量程度 未接触过暴露的女性，并确定增加的风险是否持续存在 未来五年，确定腺癌的风险是否增加 在未来五年内，确定严重医疗事故的发生率 暴露于 DES 的女性中的疾病发生率，并将这些比率与 对照组和公布的相同年龄特定发病率 疾病，以确定腹部和妇科手术的频率 在暴露于 DES 的女性中，并将这些比率与未暴露的女性进行比较 国家卫生中心提供的控制措施和费率 统计数据，并与 DESAD 项目暴露群体保持联系 以最低的费用。 这些目标将通过以下方法征求信息来实现： 邮寄调查问卷。 每年都会对每位参与者进行询问 关于医学疾病的诊断或外科手术的进行 程序。 DESAD 队列的先前经验表明， 超过 90% 的先前参与该项目的女性可以 预计会遵守信息请求。 样本量 项目中详细解释了考虑因素并表明 将有可能以 0.9 的功效检测到两倍的差异 许多常见疾病和外科手术的发生率 p=.05 水平。