IN UTERO DES EXPOSURE: CANCER AND MEDICAL ILLNESSES

子宫内暴露：癌症和疾病

• 批准号: 3174465
• 负责人: KENNETH L NOLLER
• 金额: $ 19.25万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-15 至 1989-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3174465
• 关键词: adenocarcinoma; cancer information system; cancer risk; chemical carcinogen; diethylstilbestrol; drug related neoplasm /cancer; embryo /fetus drug adverse effect; longitudinal human study; neoplasm /cancer surgery; patient /disease registry; squamous cell carcinoma

The purpose of this project is to add approximately 22,500 person years for the detection of cancer and other major medical illnesses among the 5,464 women who have previously been enrolled in the DESAD Project. This continued surveillance will enable us to accomplish five specific aims: to determine the magnitude of the excess of squamous neoplasia in exposed over unexposed women and to determine if the increased risk continues over the next five years, to determine if the risk of adenocarcinoma increases during the next five years, to determine the rates of serious medical illnesses in the DES exposed women and to compare these rates with the control groups and published age specific incidence rates for the same diseases, to determine the frequency of abdominal and gynecologic surgery among DES exposed women and to compare these rates with the unexposed controls and the rates available from the National Center for Health Statistics, and to maintain contact with the DESAD Project exposed cohort at minimal expense. These aims will be accomplished by soliciting information by the method of mailed questionnaire. Each participant will be questioned annually concerning the diagnosis of medical diseases or the performance of surgical procedures. Previous experience of the DESAD cohort has indicated that in excess of 90 percent of the women previously enrolled in the project can be expected to comply with the requests for information. The sample size considerations are explained in detail in the project and indicate that it will be possible to detect, with a power of .9, a two-fold difference in the rates of many common medical diseases and surgical procedures at the p=.05 level.

该项目的目的是增加大约22,500人年 在5,464人中发现癌症和其他重大疾病 以前参加过DESAD项目的妇女。这 持续的监督将使我们能够实现五个具体目标： 确定暴露量过多的鳞状细胞瘤的数量 并确定增加的风险是否会持续到 未来五年，为了确定腺癌的风险是否会增加 在接下来的五年里，确定重症医疗率 并将这些发病率与DES暴露妇女的发病率进行比较 控制组和公布的年龄别发病率 疾病，以确定腹部和妇科手术的频率 并将这些比率与未接触DES的妇女进行比较 国家卫生中心提供的控制措施和费率 统计数据，并与DESAD项目暴露队列保持联系 花费最少。 这些目标将通过以下方式收集信息来实现 邮寄的调查问卷。每位参与者每年都会接受询问。 关于内科疾病的诊断或外科手术的执行 程序。DESAD队列以前的经验表明，在 超过90%的以前参加该项目的女性可以 预计将遵守提供信息的要求。样本大小 在项目中详细解释了考虑因素，并指出 将有可能在0.9倍的功率下检测到两倍于 许多常见内科疾病和外科手术的发病率 P=0.05水平。