ANIHWA CALL1:Improved Understanding of Epidemiology of PPR (IUEPPR)
ANIHWA CALL1:提高对小反刍兽疫流行病学的了解 (IUEPPR)
基本信息
- 批准号:BB/L013657/1
- 负责人:
- 金额:$ 54.5万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2013
- 资助国家:英国
- 起止时间:2013 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PPR is an economically important disease, especially affecting the household economy of the poorest people, affecting mainly domestic sheep and goats in Africa, the Middle East and Asia. Its causative agent is a Morbillivirus closely related to rinderpest virus (RPV) which has just been eradicated, the first-ever animal virus eradicated And the second after smallpox virus. PPR virus (PPRV) infects a wide host range of cloven hoofed animals of the families Bovidae, Cervidae and Suidae, e.g. African buffalo Syncerus caffer, antelopes, deer, wild goat, sheep deer and pigs(Kock et al., 2006, 2008; Furley 1987; Abubakar et al., 2011). Many of these species are highly endangered (IUCN Red List 2012), especially those from mountainous and arid regions, where small livestock predominate. It is spreading rapidly despite availability of effective vaccines and diagnostic tests for PPR control. It is now in Turkey at the gateway to the European Union and threatening southern Africa. The failure to manage PPR is perhaps, linked to both cessation of RPV vaccination which was cross protective and widely used in domestic sheep and goats and inattention to the small livestock sector. Historically, PPR spill-over from infected domestic sheep and goats was observed in wild artiodactyls kept in fenced enclosures in the Middle East. More recently, natural infection was reported in free-ranging wildlife, notably inbharal in Tibet (Bao et al., 2011 & 2012), ibex in Pakistan (Abubakar et al., 2011& 2012), and wild goats in Kurdistan (Hoffmann et al., 2012). All these wildlife outbreaks were associated with PPR-infected livestock. The role of wildlife in PPR epidemiology remains unclear (Banyard et al., 2010). It is not known whether wildlife contributes to the local transmission, spread and maintenance of PPRV, thus possibly linking otherwise separate livestock grazing areas (Baron et al., 2011). PPRV wildlife data are too scarce to draw any conclusion. Diagnostic tools for PPR surveillance exist but they are not able to detect field infection rapidly, precluding rapid control and rapid field tests, such as Lateral Flow Devices and Loop-mediated isothermal amplification (LAMP), need to be developed and validated. A challenge is accessing wildlife samples, for technical and related costs. Current methods require animal capture for sampling. Recent success in obtaining antibody and virus antigen from faeces in livestock (Abubakar et al., 2012) suggest that this method might be applicable in wildlife. Urgent attention is needed at the borders of the pandemic. Turkey is the closest country to Europe that has reported outbreaks of PPR (though disease is less widespread in European Turkey in comparison to Asian Turkey, there were 20 laboratory confirmed PPR outbreaks reports in domestic sheep and goats in European Turkey 2011-2012). It hosts the same community of wild ruminants as Europe including representatives from the Caprinae (wild goats, chamois) and Cervidae. Wild goats are of high interest as the ancestor of the domestic goats; Cervidae (roe deer, red deer) are of importance because they are the most widespread and abundant wild ruminants in Europe. Theses wild ruminants might play the role of bridge species for PPRV transmission between distant populations ofinfected and health domestic sheep and goats populations. Research is urgently needed to clarify the epidemiology of PPR in wildlife species and populations (Munir, 2013), including genomic, virulence and field eco-epidemiological studies, crucial to establish an efficient and effective control strategy for PPRV.
PPR是一种重要的经济疾病,尤其影响最贫穷人口的家庭经济,主要影响非洲、中东和亚洲的家养绵羊和山羊。它的病原体是一种与牛瘟病毒(RPV)密切相关的流行性感冒病毒,它是有史以来第一种被根除的动物病毒,是继天花病毒之后的第二种病毒。PPR病毒(PPRV)广泛感染牛科、鹿科和水牛科的偶蹄动物,如非洲水牛、羚羊、鹿、野山羊、绵鹿和猪(Kock等人,2006,2008;Furley 1987;Abubakar等人,2011)。其中许多物种高度濒危(IUCN红色名单2012),特别是那些来自山区和干旱地区的物种,那里以小牲畜为主。尽管有有效的疫苗和用于控制PPR的诊断测试,但它仍在迅速传播。它现在位于土耳其,是欧盟的门户,威胁着南部非洲。未能管理PPR可能与停止RPV疫苗接种有关,RPV疫苗是交叉保护的,在家养绵羊和山羊中广泛使用,也与对小型牲畜部门的忽视有关。从历史上看,受感染的家养绵羊和山羊的PPR溢出是在中东被围栏饲养的野生偶蹄动物身上观察到的。最近,在自由放养的野生动物中报告了自然感染,特别是西藏的inbharal(Bao等人,2011和2012年)、巴基斯坦的ibex(Abubakar等人,2011和2012年)以及库尔德斯坦的野山羊(Hoffmann等人,2012年)。所有这些野生动物疫情都与感染PPR的牲畜有关。野生动物在PPR流行病学中的作用仍不清楚(Banyard等人,2010年)。目前尚不清楚野生动物是否有助于PPRV在当地的传播、传播和维护,从而可能将分开的牲畜放牧区联系在一起(Baron等人,2011年)。PPRV野生动物数据太稀少,无法得出任何结论。PPR监测的诊断工具已经存在,但它们不能快速检测现场感染,这排除了快速控制和快速现场测试,如侧流设备和环路介导的等温放大(LAMP)需要开发和验证。一个挑战是获取野生动物样本,以获得技术和相关成本。目前的方法需要捕获动物进行采样。最近成功地从家畜粪便中获得抗体和病毒抗原(Abubakar等人,2012年),这表明该方法可能适用于野生动物。在大流行的边界需要紧急关注。土耳其是报告发生PPR疫情的距离欧洲最近的国家(尽管与亚洲土耳其相比,欧洲土耳其的疫情不那么普遍,但2011-2012年,欧洲土耳其有20起实验室确认的PPR家养绵羊和山羊疫情报告)。它拥有与欧洲相同的野生反刍动物群落,包括来自角羊亚科(野山羊,查莫伊)和鹿科的代表。野生山羊作为家养山羊的祖先而备受关注;鹿科(鹿科,马鹿)很重要,因为它们是欧洲分布最广、数量最多的野生反刍动物。这些野生反刍动物可能是猪伪狂犬病病毒在受感染和健康的家养绵羊和山羊群体之间传播的桥梁物种。迫切需要研究以澄清PPR在野生动物物种和种群中的流行病学(Munir,2013),包括基因组、毒力和现场生态流行病学研究,这对建立有效和有效的PPRV控制战略至关重要。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Re-emergence of Peste des Petits Ruminants virus in 2015 in Morocco: Molecular characterization and experimental infection in Alpine goats
- DOI:10.1016/j.vetmic.2016.11.006
- 发表时间:2016-12-25
- 期刊:
- 影响因子:3.3
- 作者:Fakri, F.;Embarki, T.;Elharrak, M.
- 通讯作者:Elharrak, M.
Peste des petits ruminants (PPR): A neglected tropical disease in Maghreb region of North Africa and its threat to Europe.
- DOI:10.1371/journal.pone.0175461
- 发表时间:2017
- 期刊:
- 影响因子:3.7
- 作者:Baazizi R;Mahapatra M;Clarke BD;Ait-Oudhia K;Khelef D;Parida S
- 通讯作者:Parida S
Persistence of Lineage IV Peste-des-petits ruminants virus within Israel since 1993: An evolutionary perspective.
- DOI:10.1371/journal.pone.0177028
- 发表时间:2017
- 期刊:
- 影响因子:3.7
- 作者:Clarke B;Mahapatra M;Friedgut O;Bumbarov V;Parida S
- 通讯作者:Parida S
Molecular characterization of Peste des petits ruminants viruses in the Marmara Region of Turkey.
- DOI:10.1111/tbed.13095
- 发表时间:2019-03
- 期刊:
- 影响因子:4.3
- 作者:Altan E;Parida S;Mahapatra M;Turan N;Yilmaz H
- 通讯作者:Yilmaz H
Molecular detection, isolation and characterization of Peste-des-petits ruminants virus from goat milk from outbreaks in Bangladesh and its implication for eradication strategy.
- DOI:10.1111/tbed.12911
- 发表时间:2018-12
- 期刊:
- 影响因子:4.3
- 作者:Clarke BD;Islam MR;Yusuf MA;Mahapatra M;Parida S
- 通讯作者:Parida S
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{{ truncateString('Satya Parida', 18)}}的其他基金
Next generation peste-des-petits ruminats (PPR) vaccines that differentiate between infected and vaccinated animals (DIVA) - proof of concept in sheep
下一代小反刍兽疫 (PPR) 疫苗可区分受感染动物和已接种动物 (DIVA) - 在绵羊身上进行概念验证
- 批准号:
BB/T004096/1 - 财政年份:2020
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
Improving the duration of immunity for FMD vaccines
提高口蹄疫疫苗的免疫力持续时间
- 批准号:
BB/N012682/1 - 财政年份:2016
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
Understanding the immune mechanism of host disease resistance and development of marker vaccines and DIVA tests for Peste des Petits Ruminants (PPR)
了解宿主抗病的免疫机制以及针对小反刍兽疫 (PPR) 标记疫苗和 DIVA 检测的开发
- 批准号:
BB/L004801/1 - 财政年份:2014
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
UK-India Partnership for the control of FMD and PPR
英国与印度建立口蹄疫和小反刍兽疫控制伙伴关系
- 批准号:
BB/J020478/1 - 财政年份:2012
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
Improving the quality of FMD vaccines by understanding the correlation of vaccine-induced protection with humoral and cellular immune responses
通过了解疫苗诱导的保护与体液和细胞免疫反应的相关性来提高 FMD 疫苗的质量
- 批准号:
BB/H009175/1 - 财政年份:2011
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
UK-China partnership to control Peste-des-petits-ruminants (PPR)
中英合作控制小反刍兽疫 (PPR)
- 批准号:
BB/I026138/1 - 财政年份:2011
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
相似海外基金
ANIHWA call1 TURKEYWELFARE
ANIHWA call1 土耳其福利
- 批准号:
BB/L012022/1 - 财政年份:2014
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant
ANIHWA CALL1:Improved Understanding of Epidemiology of PPR (IUEPPR)
ANIHWA CALL1:提高对小反刍兽疫流行病学的了解 (IUEPPR)
- 批准号:
BB/L013592/1 - 财政年份:2013
- 资助金额:
$ 54.5万 - 项目类别:
Research Grant