THE CHEMISTRY OF TECHNETIUM RELATED TO NUCLEAR MEDICINE

与核医学相关的锝化学

• 批准号: 3172755
• 负责人: Alun Gareth Jones
• 金额: $ 21.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-02-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3172755
• 关键词: chemical bond; chemical structure function; chemical synthesis; electron probe spectrometry; ligands; nuclear magnetic resonance spectroscopy; nuclear medicine; oxidation; radionuclide diagnosis; radiopharmacology; radiotracer; stereochemistry; technetium

This investigation is designed to achieve a greater understanding the chemistry of technetium, and to use this knowledge in the rational design of new radiopharmaceuticals incorporating the radionuclide 99mTc. Beginning with already characterized compounds in well-defined oxidation states complexes will be prepared, isolated and studied using methods which have been successfully applied to the coordination chemistry of other transition metals. The aim of the synthetic program is to give a profile of the oxidation state, stereochemistry, nature of the bonding and the relative ligand affinities of technetium compounds. As the systematics of the element's behavior emerge, this information will be applied to the designing and synthesizing of materials which show potential as radiodiagnostic agents. These will then be evaluated in appropriate animal models.

这项调查的目的是为了更好地了解化学 ，并将这一知识用于合理设计新的 含有放射性核素99mTc的放射性药物。 从明确定义的氧化态的已经表征的化合物开始 将使用已有的方法来制备、分离和研究络合物 成功地应用于其他过渡金属的配位化学。 合成程序的目的是给出氧化状态的轮廓， 立体化学，键的性质和相对配体亲和力 氚化合物。随着元素行为的系统学的出现，这 信息将被应用于材料的设计和合成， 显示出作为放射诊断试剂的潜力。然后将在以下方面进行评估 合适的动物模型。