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TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE

TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE
核医学中的锝和铼
批准号:
2856237
负责人:
Alun Gareth Jones
金额:
$55.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-02-01 至 2000-03-31

项目摘要

项目成果

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中文摘要
翻译
人造元素锝,以其短命的伽马射线的形式
英文摘要
The artificial element technetium, in the form of its short-lived gamma ray emitting radionuclide 99mTc, plays a very important role in routine nuclear medicine imaging. More than 85% of all procedures in the USA involve the administration of a 99mTc-labeled radiopharmaceutical. This renewal application describes a continuing program of research that combined basic chemical studies of the element together with applications of that chemistry towards the design of new imaging agents. In addition a parallel program will explore the chemistry of the closely related metallic element rhenium and its applications in radiotherapy. The basic studies of technetium will include the use of new synthetic intermediates discovered in the current cycle to explore the rapidly developing low-oxidation-state chemistry, the use of nitrogen donor ligands to form new complexes in low and high oxidation states, and an investigation of its organometallic chemistry. New strategies will be investigated for conjugation of technetium to biologically active molecules using several different classes of complexes that leave free coordinating sites for the attachment of biological ligands. The first application of the chemistry will involve an investigation of a variety of cationic technetium complexes as myocardial imaging agents that are sensitive to the metabolic state of the tissue. Such agents would be important in the evaluation of salvageable tissue following an ischemic event. The second area will explore several avenues towards tumor detection, including relatively simple cationic complexes and 99mTc-labeled natural killer (NK) cells. In the applications of rhenium chemistry, reliable methods for synthesizing required compounds at tracer concentrations will be devised. This will essentially parallel earlier developments in technetium chemistry. This chemistry will then be applied to a search for soluble agents suitable for radiation synovectomy, particularly for treatment of rheumatoid arthritis and pigmented villonodular synovitis. The use of soluble agents may allow a wider use of this therapy in joints smaller than the knee and ankle.
期刊论文(18)
专著(0)
科研奖励(0)
会议论文
A new Tc-99m-labeled myocardial imaging agent, hexakis(t-butylisonitrile)-technetium(I) [Tc-99m TBI]: initial experience in the human.
一种新型 Tc-99m 标记心肌显像剂,六(叔丁基异腈)-锝(I) [Tc-99m TBI]:人体初步经验。
DOI: --
发表时间: 1984
期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子: --
作者: [Holman,BL, Jones,AG, Lister-James,J, Davison,A, Abrams,MJ, Kirshenbaum,JM, Tumeh,SS, English,RJ]
通讯作者: English,RJ
DOI: --
发表时间: 1992-08
期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子: --
作者: [P. A. Carvalho;Mary L. Chiu;J. Kronauge;M. Kawamura;Alun G. Jones;B. Holman;D. Piwnica-worms]
通讯作者: P. A. Carvalho;Mary L. Chiu;J. Kronauge;M. Kawamura;Alun G. Jones;B. Holman;D. Piwnica-worms
A new approach to labeling cells with technetium-99m, Part I. Preparation of modified polylysine and in vitro cell labeling.
用 Technetium-99m 标记细胞的新方法,第一部分。修饰聚赖氨酸的制备和体外细胞标记。
DOI: 10.1016/0969-8051(95)02071-3
发表时间: 1996
期刊: Nuclear medicine and biology
影响因子: 3.1
作者: [Mahmood,A, Delmon-Moingeon,LI, Limpa-Amara,N, Davison,A, Jones,AG]
通讯作者: Jones,AG
Mediastinal lymphoscintigraphy in ovarian cancer using intraperitoneal autologous technetium-99m-labelled erythrocytes.
使用腹腔内自体 99m 标记红细胞进行卵巢癌纵隔淋巴闪烁显像。
DOI: 10.1259/0007-1285-54-638-126
发表时间: 1981
期刊: The British journal of radiology
影响因子: --
作者: [Kaplan,WD, Bloomer,WD, Jones,AG, Federschneider,J, Knapp,RC]
通讯作者: Knapp,RC
13
    TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE
    • 批准号:
      2088804
    • 项目类别:
    • 资助金额:
      $53.07万
    • 财政年份:
      1977
    • 负责人:
      Alun Gareth Jones
    • 依托单位:
    TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE
    • 批准号:
      2633759
    • 项目类别:
    • 资助金额:
      $53.67万
    • 财政年份:
      1977
    • 负责人:
      Alun Gareth Jones
    • 依托单位:
    THE CHEMISTRY OF TECHNETIUM RELATED TO NUCLEAR MEDICINE
    • 批准号:
      3172756
    • 项目类别:
    • 资助金额:
      $37.6万
    • 财政年份:
      1977
    • 负责人:
      Alun Gareth Jones
    • 依托单位:
    TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE
    • 批准号:
      6512439
    • 项目类别:
    • 资助金额:
      $49.34万
    • 财政年份:
      1977
    • 负责人:
      Alun Gareth Jones
    • 依托单位:
    国内基金
    海外基金
    Acoustic Cardiography在心力衰竭患者危险分层及预后评估中的应用研究
    • 批准号:
      81300244
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      23.0万元
    • 批准年份:
      2013
    • 负责人:
      王上
    • 依托单位: