LIPID DIET EFFECTS ON COLON TUMOR GROWTH AND METASTASES

脂质饮食对结肠肿瘤生长和转移的影响

• 批准号: 3176229
• 负责人: SELWYN A BROITMAN
• 金额: $ 16.06万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3176229
• 关键词: carcinogenesis; dietary lipid; metastasis; neoplasm /cancer transplantation; nutrition aspect of cancer; nutrition related neoplasm /cancer; nutrition related tag

Long term objectives of this laboratory are to identify nutritional factors which contribute to the high incidence of colon cancer in Western cultures. Experimentally it has been suggested that dietary fat may serve in a promotional capacity in some manner following colon tumor initiation in two stage carcinogenesis. Although the relationship of dietary lipids to pre-initiation and promotional events in tumorigenesis are well studied, there is little information regarding the nutritional consequences on tumor behavior following tumor promotion, i.e., upon tumor growth, its spread, and its propensity to metastasize. It is hypothesized that the quality and quantity of dietary fat and cholesterol may influence tumor latency time, growth, pulmonary colonization, propensity to metastasize, lipid composition (profile) and demise of its host. To test this, the following will be accomplished: ascertain the relationship of diets containing varying levels of polyunsaturated fat (safflower oil) and saturated fat (hydrogenated coconut oil) with and without cholesterol to the growth and development of a highly metastatic CT-26 and minimally metastatic CT-51 transplantable colon carcinomas in the BALB/c mouse. The relationship of dietary interventions will be compared with the tumor implanted in the flank or surgically implanted into the colon. Differences in metastatic behavior between tumors at each site will be explored. Attention will be directed towards dietary influences on tumor behavior and the lipid profile of both tumors at each site. In addition the relationship of each tumor to the lipid profile of the host bowel, liver, and serum cholesterol levels will be assessed. It is very likely that nutritional interventions may influence the growth and metastatic spread of colon tumors. It is anticipated that these studies should provide 1) answers regarding differences or similarities between the effects of lipid nutriture on colon tumor induction and promotion and tumor behavior post-promotion; 2) a better understanding between lipid nutrition and colon cancer; 3) insights into the relationship between dietary cholesterol, hypocholesterolemia and colon cancer; and 4) guidelines for exploring possibilities of nutritional interventions aimed at the management of patients with colon cancer following resection or in conjunction with radiation or chemotherapy.

该实验室的长期目标是确定营养因素 结肠癌的发病率很高， cultures. 实验表明，膳食脂肪可能有助于 在结肠肿瘤发生后， 在两个阶段的致癌作用中。 虽然饮食中的脂质 对肿瘤发生中的预启动和促进事件进行了很好的研究， 关于营养对肿瘤的影响， 肿瘤促进后的行为，即，在肿瘤生长，扩散， 以及它的转移倾向 据推测，膳食脂肪的质量和数量， 胆固醇可能会影响肿瘤的潜伏期，生长，肺 定植、转移倾向、脂质组成（特征）和 宿主的死亡。 为了测试这一点，将完成以下工作： 确定饮食中含有不同水平的 多不饱和脂肪（红花油）和饱和脂肪（氢化椰子 油）与胆固醇和无胆固醇的生长和发展的高度 转移性CT-26和微转移性CT-51可移植结肠 Balb/c小鼠的癌症。 饮食干预的关系 将与植入侧腹或手术的肿瘤进行比较 植入结肠 之间转移行为的差异 将探查每个部位的肿瘤。 注意力将集中在 饮食对肿瘤行为和两种肿瘤的脂质分布的影响 在每个站点。 此外，每个肿瘤与脂质的关系 宿主肠道、肝脏和血清胆固醇水平的概况将被 评估。 营养干预很可能会影响 结肠肿瘤的生长和转移扩散。 预计各国 这些研究应提供1）关于差异的答案，或 脂质营养对结肠肿瘤作用的相似性 诱导和促进以及促进后的肿瘤行为; 2）更好地 了解脂质营养和结肠癌之间的关系; 3）深入了解 膳食胆固醇、低胆固醇血症与结肠关系 癌症;和4）探索营养可能性的指南 针对结肠癌患者管理的干预措施 切除后或与放疗或化疗联合。