DIAGNOSIS OF LEUKEMIA (CML) ONCOGENE (C-ABL) EXPRESSION

白血病 (CML) 癌基因 (C-ABL) 表达的诊断

• 批准号: 3176620
• 负责人: ROBERT P GALE
• 金额: $ 9.94万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-06-01 至 1988-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3176620
• 关键词: Abelson leukemia virus; Retroviridae disease; chromosome translocation; diagnostic tests; gel electrophoresis; gene expression; genetic manipulation; genetic recombination; human subject; karyotype; messenger RNA; molecular cloning; molecular oncology; myelogenous leukemia; myeloproliferative neoplasm; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer genetics; oncogenes; oncogenic virus; oncoproteins; transforming virus; viral leukemia; viral leukemogenesis; virus RNA

The object of this project is to apply results of recent advances in molecular biology, specifically molecular cloning of cellular oncogenes, synthesis of oncogene related peptides, and in situ chromosome hybridization to the diagnosis, evaluation, and monitoring of human leukemias--specifically to chronic myelogenous leukemia (CML). A novel 8 Kb RNA hybridizing with the normal, cellular homologue of the transforming gene of Abelson murine leukemia virus (c-abl) has been detected in patients with CML and the t(9,22) translocation (Ph' chromosome). It is not present in CML without the t(9,22) or other leukemias with rare exceptions. We will analyze patients with CML and related myeloproliferative disorders (Ph' negative CML) for this novel c-abl RNA. The objective is to define more precisely the Ph' negative leukemia and to correlate c-abl expression with disease phase and response to therapy. These RNA studies are to be complemented with analysis of c-abl related patients and by in situ chromosome hybridization using a v-abl probe. These studies will allow a more precise (molecular) definition of CML and related human leukemias. (6)

这个项目的目的是应用最新进展的结果

项目成果

Blood-derived haematopoietic cell transplants: blood to blood?

血源性造血细胞移植：血对血？

• DOI: 10.1016/0140-6736(91)91583-g
• 发表时间: 1991
• 期刊: Lancet (London, England)
• 作者: Henon,PR;Butturini,A;Gale,RP
• 通讯作者: Gale,RP

Do oncogenes determine clinical features in chronic myeloid leukaemia?

癌基因决定慢性粒细胞白血病的临床特征吗？

• DOI: 10.1016/s0140-6736(87)90594-0
• 发表时间: 1987
• 期刊: Lancet (London, England)
• 作者: Dreazen,O;Klisak,I;Rassool,F;Goldman,JM;Sparkes,RS;Gale,RP
• 通讯作者: Gale,RP

Where does transformation occur in acute leukemia?

急性白血病的转化发生在哪里？

• DOI: 10.1016/0145-2126(91)90188-y
• 发表时间: 1991
• 期刊: Leukemia research
• 影响因子: 2.7
• 作者: Sun,GX;Wormsley,S;Sparkes,RS;Naeim,F;Gale,RP
• 通讯作者: Gale,RP

B cell acute lymphoblastic leukemia (ALL) in donor cells following bone marrow transplantation for T cell ALL.

T 细胞 ALL 骨髓移植后供体细胞中的 B 细胞急性淋巴细胞白血病 (ALL)。

• 发表时间: 1988
• 期刊: Bone marrow transplantation
• 影响因子: 4.8
• 作者: Feig,SA;Dreazen,O;Simon,M;Wiley,F;Schreck,R;Gale,RP
• 通讯作者: Gale,RP

bcr genes and transcripts.

bcr 基因和转录本。

• 发表时间: 1988
• 期刊: Oncogene
• 影响因子: 8
• 作者: Lifshitz,B;Fainstein,E;Marcelle,C;Shtivelman,E;Amson,R;Gale,RP;Canaani,E
• 通讯作者: Canaani,E