A PROGRAM IN BONE MARROW TRANSPLANTATION

在过去的九年里，加州大学洛杉矶分校的移植生物学部门一直在 参与一项持续的骨髓移植计划 再生障碍性贫血、白血病、癌症和 免疫缺陷疾病。这些患者中的许多人已经成为长期的 幸存者，但仍有相当多的问题需要解决，包括 预防移植物排斥反应、移植物抗宿主病(GVHD)、延迟 免疫重建和间质性肺炎。这份提案概述了 我们正在进行的三个主要计划领域的研究：(1) 骨髓移植；(3)移植中的间质性肺炎 收件人。这些研究包括对狗的临床前研究，以及 对照临床试验。拟议项目的目标是 骨髓移植在临床治疗中的应用进展 通过深入分析人类疾病移植的基本问题 动物生物学和适当的临床试验。

For the past nine years, the Transplantation Biology Unit at UCLA has been involved in a continuing program of bone marrow transplantation in the treatment of patients with aplastic anemia, leukemia, cancer, and immunodeficiency diseases. Many of these patients have become long-term survivors but considerable problems remain to be addressed including prevention of graft rejection, graft-vs-host disease (GVHD), delay of immune reconstitution and interstitial pneumonia. This proposal outlines our ongoing studies in three major program areas: (1) the immunobiology of marrow transplantation, and (3) interstitial pneumoia in transplant recipients. These studies include preclinical studies in dogs, and controlled clinical trials. The objective of the proposed project is to continue progress in the application of bone marrow transplantation to human disease by an in-depth analysis of basic problems of transplantation biology in animals and by appropriate clinical trials.