PREFERENTIAL KILLING OF MELANIZED TISSUES

优先杀死黑色化组织

• 批准号: 3187194
• 负责人: PETER M. CORRY
• 金额: $ 14.08万
• 依托单位: WILLIAM BEAUMONT HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1989-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3187194
• 关键词: DNA repair; biopsy; bleomycin; cis platinum compound; clinical biomedical equipment; combination cancer therapy; computed axial tomography; computer assisted patient care; cyclophosphamide; cytotoxicity; flow cytometry; human subject; ionizing radiation; magnetism; mitomycin C; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer therapy; neoplasm /cancer thermotherapy; nitrosourea; radiation therapy dosage; tissue /cell culture; ultrasound therapy

The major objective of this proposal is the development of ultrasound as a modality for the treatment of cancer in humans with nonionizing radiation. Continuous wave ultrasound in the frequency range of 300 kHz to 2.5 mHz and with intensities up to 5 W/cm squared will be employed using single and multiple transducer systems of our own design and construction. Pulsed ultrasound will also be used for the treatment of human malignant melanoma at intensities up to 100 w/cm squared and duty cycles varying between one and ten percent to test the hypothesis that "non-thermal" interactions resulting from the amorphous semiconductor nature of the melanin may be exploited in the treatment of this disease. Since the interactions of ultrasound inevitably result in temperature evaluation, treatment of human tumors with magnetic induction hyperthermia will also be carried out in the temperature range beween 43 and 53 C. The efficiacy of these two modalities will then be compared in a wide variety of histological types of tumors. In addition to the application of these modalities by themselves, they will als be combined with ionizing radiation and chemotherapeutic drugs in appropriate regimens. In vitro investigators using tissue culture systems as well as animal tumor and human tumor biopsy specimens will also be carried out to elucidate possible mechanisms for the cytotoxic activity of the proposed modalities and provide guidance for the actual tumor therapy regimens. Studies into the development of prognostic tests for hyperthermic therapy are also proposed.

该提案的主要目的是发展超声 非离子辐射的人类治疗癌症的方式。 连续波超声在300 kHz至2.5 MHz的频率范围内 使用单个和 我们自己的设计和构建的多个传感器系统。 脉冲 超声也将用于治疗人类恶性黑色素瘤 以高达100 W/cm平方的强度，占空比在一个之间变化 和百分之十，以检验“非热”相互作用的假设 黑色素的无定形半导体性质可能是 在治疗这种疾病中被利用。 由于 超声不可避免地会导致温度评估，对人类的处理 具有磁性诱导高温的肿瘤也将在 43和53 C之间的温度范围 然后，将在多种组织学类型的类型中比较方式 肿瘤。 除了自己应用这些方式外， 它们将与电离辐射和化学治疗相结合 适当方案中的毒品。 使用组织培养的体外研究者 系统以及动物肿瘤和人类肿瘤活检标本也将 被执行以阐明细胞毒性活性的可能机制 拟议的方式，并为实际肿瘤提供指导 治疗方案。 研究预后测试的发展 还提出了高温治疗。