GROWTH REGULATION IN NORMAL AND TRANSFORMED PHAGOCYTES
GROWTH REGULATION IN NORMAL AND TRANSFORMED PHAGOCYTES
批准号:
3191083
负责人:
BEN D CHEN
金额:
$12.77万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-05-01 至 1995-02-28
关键词:
biological signal transduction cell differentiation cell growth regulation cell transformation colony stimulating factor cytokine receptors laboratory mouse leukocyte activation /transformation monocyte neoplastic cell culture for noncancer research phosphorylation protooncogene receptor coupling tissue /cell culture
中文摘要
单核吞噬细胞的增殖和分化
英文摘要
The proliferation and differentiation of mononuclear phagocytes are
regulated by a group of hemopoietic growth factors known as colony-
stimulating factors (CSFs). In mouse, most macrophage precursor cells
display several types of CSF receptors simultaneously and respond to CSFs
either alone or in combination. Despite their seeming redundancy and
overlap in biologic effects, CSFs act in a hierarchical and coordinated
manner toward the control of macrophage proliferation and differentiation.
Receptor binding assay indicates that although CSFs do not share each
other's receptor sites, they can induce a rapid transient down-regulation
of other CSF receptors. However, although J774 monocyte-like tumor cells
display multiple CSF receptor systems, they do not exhibit the receptor
trans-modulation seen in their normal counterparts. Our working hypothesis
is that various CSF receptors are linked through a signaling network by
which the processes of proliferation and differentiation in hemopoietic
cells are coupled. It is thought that the un-coupling between CSF
receptors in hemopoietic cells may lead to the arrested differentiation and
uncontrolled proliferation characteristic of leukemic cells. To verify
that hypothesis, we will first study the biochemical changes associated
with receptor trans-modulation and their biologic significance in normal
macrophages and their leukemic counterparts, J774 cells. Next, we will
study the biochemical basis responsible for receptor-receptor interaction
and determine the causes leading to receptor-uncoupling seen in leukemic
cells. Finally, we will study whether the biologic responses associated
with receptor trans-modulation are regulated at genetic levels as well.
The overall objective of this proposal is to gain more insight into the
biologic significance of receptor-receptor interaction and the role of this
interaction in linking the processes of proliferation and differentiation
in hemopoietic cells.
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GROWTH REGULATION IN NORMAL AND TRANSFORMED PHAGOCYTES
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批准号:3191084
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项目类别:
-
资助金额:$13.28万
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财政年份:1990
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负责人:BEN D CHEN
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依托单位:
GROWTH REGULATION IN NORMAL AND TRANSFORMED PHAGOCYTES
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批准号:3191081
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项目类别:
-
资助金额:$11.23万
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财政年份:1990
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负责人:BEN D CHEN
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依托单位:
GROWTH REGULATION IN NORMAL AND TRANSFORMED PHAGOCYTES
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批准号:2092550
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项目类别:
-
资助金额:$13.53万
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财政年份:1990
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负责人:BEN D CHEN
-
依托单位:
GROWTH REGULATION IN NORMAL AND TRANSFORMED PHAGOCYTES
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批准号:3191082
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项目类别:
-
资助金额:$12.28万
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财政年份:1990
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负责人:BEN D CHEN
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依托单位:
GM-CSF RECEPTOR/LYN INTERACTION AND MYELOID LEUKEMIAS
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批准号:2443324
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项目类别:
-
资助金额:$15.37万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY-STIMULATING FACTOR
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批准号:3135688
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项目类别:
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资助金额:$11.96万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY-STIMULATING FACTOR
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批准号:2062230
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项目类别:
-
资助金额:$13.54万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
GM-CSF RECEPTOR/LYN INTERACTION AND MYELOID LEUKEMIAS
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批准号:2733321
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项目类别:
-
资助金额:$15.99万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY-STIMULATING FACTOR
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批准号:3135689
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项目类别:
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资助金额:$12.52万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH--ROLE OF COLONY-STIMULATING FACTOR
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批准号:3135690
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项目类别:
-
资助金额:$13.02万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY STIMULATING FACTOR
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批准号:3135687
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项目类别:
-
资助金额:$13.43万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY STIMULATING FACTOR
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批准号:3135691
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项目类别:
-
资助金额:$13.49万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
GM-CSF RECEPTOR/LYN INTERACTION AND MYELOID LEUKEMIAS
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批准号:2895819
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项目类别:
-
资助金额:$16.63万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
GM-CSF RECEPTOR/LYN INTERACTION AND MYELOID LEUKEMIAS
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批准号:2011241
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项目类别:
-
资助金额:$14.78万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY-STIMULATING FACTOR
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批准号:3135685
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项目类别:
-
资助金额:$11.52万
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财政年份:1987
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负责人:BEN D CHEN
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依托单位:
MACROPHAGE GROWTH: ROLE OF COLONY STIMULATING FACTOR
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批准号:3135684
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项目类别:
-
资助金额:$9.9万
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财政年份:1986
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负责人:BEN D CHEN
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依托单位:
INTERACTION OF COLONY-STIMULATING FACTOR WITH MONONUCLEA
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批准号:3445553
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项目类别:
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资助金额:$5.8万
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财政年份:1984
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负责人:BEN D CHEN
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依托单位:
海外基金