INCIDENTAL INFECTIOUS DISEASES AS COFACTORS

偶发传染病作为辅助因素

• 批准号: 3194500
• 负责人: NIELS C PEDERSEN
• 金额: $ 23.17万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-16 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3194500
• 关键词: AIDS; Chlamydiaceae; Coronaviridae; HIV infections; Herpesviridae; Toxoplasma; cats; disease /disorder model; feline immunodeficiency virus; feline leukemia /sarcoma virus; germ free condition; model design /development; secondary infection; virus virus interaction

Various cofactors are known to increase the rate of HIV infection and to cause asymptomatic seropositive individuals to more rapidly develop AIDs. The role of common infectious diseases as cofactors in enhancing both virus transmission and disease progression is of particular interest in human medicine but is difficult to study. Humans cannot be purposefully infected, pathogen free populations do not exist, and people cannot be put into sterile environments once they are infected. This aspect of HIV infection can be better studied using an appropriate animal model. Feline Immunodeficiency Virus (FIV) infection might provide such a model. Specific pathogen free (SPF) cats are available, experimental infections can be created, and various infectious disease exposing environments can be artificially recreated. We propose to study the role of secondary infections as cofactors in FIV transmission and disease progression in two way: 1) by exposing FIV-infected and non-infected specific pathogen free cats to a wide range of common feline pathogens by natural means, i.e. by contact exposure with conventional cats housed in the same rooms, and 2) by sequentially infecting FIV-infected and non- infected specific pathogen free cats with 7 common feline pathogens, feline herpesivirus, feline calicivirus, feline enteric coronavirus, Chlamydia psittaci, hemobartonella felis, Toxoplasma gondii, and feline leukemia virus. The purpose of the first study is to see if continuous exposure to many different secondary disease agents enhances the transmission of FIV between infected and susceptible cats or accelerates the progression from the asymptomatic to the AIDS-phase of illness. The aim of the second study is to see whether FIV infection in asymptomatic FIV-infected cats alters the normal clinical and immunologic manifestation of 7 common infectious diseases of cats, alters the carrier state that follow the clinical phase of these illnesses, affects the normal perturbations in lymphocyte blastogenesis that appear transiently during and after most common infectious processes. Conversely, we are interested in seeing whether coinfection of FIV infected cats with any of these agents alters the levels of FIV in their blood or accelerates their immunologic decline.

已知多种辅助因子会增加 HIV 感染率 并导致无症状血清反应阳性个体更快地 开发艾滋病。 常见传染病作为辅助因子的作用 增强病毒传播和疾病进展的作用 对人类医学特别感兴趣，但很难研究。 人类不能被有目的地感染，无病原体人群 不存在，人们不能被放入无菌环境中 一旦他们被感染。 HIV感染这方面可以更好 使用适当的动物模型进行研究。 猫科动物免疫缺陷 病毒（FIV）感染可能提供这样的模型。 具体的 无病原体（SPF）猫是可用的，实验性感染可以 创造各种传染病暴露环境 可以人工重建。 我们建议研究继发感染作为辅助因子的作用 FIV 传播和疾病进展有两种方式：1) 暴露无 FIV 感染和未感染特定病原体的猫 通过自然方式对抗多种常见的猫科病原体，即 通过与饲养在同一环境中的传统猫接触暴露 房间，以及 2) 通过依次感染 FIV 感染者和非感染者 无特定病原体感染的猫与 7 只普通猫科动物 病原体, 猫疱疹病毒, 猫杯状病毒, 猫肠道病毒 冠状病毒、鹦鹉热衣原体、猫血巴尔通体、弓形虫 弓形虫和猫白血病病毒。 第一次学习的目的 是看是否持续接触许多不同的次要 疾病病原体增强了感染者之间 FIV 的传播 和易感猫或加速从 艾滋病阶段无症状。 第二个目标 研究目的是观察无症状 FIV 感染者是否存在 FIV 感染 猫改变了正常的临床和免疫学表现 猫的7种常见传染病，改变了携带者状态 跟踪这些疾病的临床阶段，影响正常 短暂出现的淋巴细胞胚细胞发生扰动 在最常见的感染过程期间和之后。 相反，我们 有兴趣了解 FIV 感染猫是否同时感染 使用这些药物中的任何一种都会改变血液中 FIV 的水平 或加速他们的免疫衰退。