Rescuing Antibiotics from Bacterial Resistance

拯救抗生素免受细菌耐药性

• 批准号: BB/M015394/1
• 负责人: David Keith Summers
• 金额: $ 2万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM015394%2F1
• 关键词: Rescuing; Antibiotics; Bacterial; Resistance

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment.

• DOI: 10.1128/mbio.00909-21
• 发表时间: 2021-08-31
• 期刊: mBio
• 影响因子: 6.4
• 作者: Goode O;Smith A;Zarkan A;Cama J;Invergo BM;Belgami D;Caño-Muñiz S;Metz J;O'Neill P;Jeffries A;Norville IH;David J;Summers D;Pagliara S
• 通讯作者: Pagliara S

Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters.

抑制吲哚的产生会增加喹诺酮类抗生素对大肠杆菌持续存在的活性。

• DOI: 10.1038/s41598-020-68693-w
• 发表时间: 2020
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zarkan A