FERROMAGNETIC HYPERTHERMIA & IODINE-125 BRACHYTHERAPY

铁磁热疗

• 批准号: 3193500
• 负责人: RICHARD A STEEVES
• 金额: $ 10.95万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3193500
• 关键词: cytotoxicity; iron; laboratory mouse; laboratory rabbit; magnetism; radionuclide therapy; relative biological effectiveness

Ferromagnetic heating shares the advantages of other types of interstitial hyperthermia that the heating is delivered from within the tumor with more comprehensive heating of the entire tumor volume and greater ease of thermometry. Another advantage unique to ferromagnetic hyperthermia is that the nickel and copper alloy converts energy from a surrounding EM field into heat energy, but only up to a preset level (e.g., 45 degree C). This heat diffuses in a predictable fashion throughout normal rabbit muscle tissues as shown in preliminary experiments conducted in our laboratory. We also showed that it is feasible to combine radioactive iodine (I-125) seeds with ferromagnetic thermoseeds so that ionizing radiation and interstitial hyperthermia can be delivered simultaneously. Our goal is to optimize the combination of these two treatment modalities by studying the effect of several physical and radiobiological factors on the thermal enhancement ratio (TER) of ferromagnetic hyperthermia with I-125 brachytherapy for the local control of transplanted neoplasms in rabbits. Variables to be examined will be those with the greatest potential for clinical impact: spacing I-125 and thermoseeds within the implant, as well as timing, dose and fractionation of each treatment modality. We will also compare the efficacy of concomitant versus sequential hyperthermia and low- dose rate brachytherapy, in order to test our hypothesis that concomitant therapy with both modalities given simultaneously will lead to the greater therapeutic benefit than conventional (sequential) therapy.

铁磁加热具有其他类型的间隙加热的优点 热疗是指加热是从肿瘤内部传递的，而且 对整个肿瘤体积进行全面加热，更容易 测温仪。铁磁热疗的另一个独特优势是 镍和铜合金从周围的电磁场中转换能量 磁场转化为热能，但只能达到预设的水平(例如，45摄氏度)。 这种热能以一种可预见的方式在正常兔肌肉中扩散。 在我们实验室进行的初步实验中显示的组织。 我们还证明了结合放射性碘(I-125)是可行的。 具有铁磁性热种的种子，使电离辐射和 间质热疗可同时进行。我们的目标是 通过研究这两种治疗方式的组合来优化 几种物理和放射生物因素对热效应的影响 I-125铁磁热疗的增强比(TER) 近距离放射治疗对兔移植瘤局部控制的研究。 要考察的变量将是那些最有可能 临床影响：植入物内的间隔I-125和热播撒 作为每种治疗方式的时机、剂量和分级。我们还将 比较同期热疗与序贯热疗和低热疗的疗效。 剂量率近距离治疗，以检验我们的假设伴随而来 两种方法同时进行的治疗将导致更大的 治疗效果优于传统(序贯)疗法。