FERROMAGNETIC HYPERTHERMIA & IODINE-125 BRACHYTHERAPY

铁磁热疗

• 批准号: 3193497
• 负责人: RICHARD A STEEVES
• 金额: $ 10.96万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3193497
• 关键词: cytotoxicity; iron; laboratory mouse; laboratory rabbit; magnetism; radionuclide therapy; relative biological effectiveness

Ferromagnetic heating shares the advantages of other types of interstitial hyperthermia that the heating is delivered from within the tumor with more comprehensive heating of the entire tumor volume and greater ease of thermometry. Another advantage unique to ferromagnetic hyperthermia is that the nickel and copper alloy converts energy from a surrounding EM field into heat energy, but only up to a preset level (e.g., 45 degree C). This heat diffuses in a predictable fashion throughout normal rabbit muscle tissues as shown in preliminary experiments conducted in our laboratory. We also showed that it is feasible to combine radioactive iodine (I-125) seeds with ferromagnetic thermoseeds so that ionizing radiation and interstitial hyperthermia can be delivered simultaneously. Our goal is to optimize the combination of these two treatment modalities by studying the effect of several physical and radiobiological factors on the thermal enhancement ratio (TER) of ferromagnetic hyperthermia with I-125 brachytherapy for the local control of transplanted neoplasms in rabbits. Variables to be examined will be those with the greatest potential for clinical impact: spacing I-125 and thermoseeds within the implant, as well as timing, dose and fractionation of each treatment modality. We will also compare the efficacy of concomitant versus sequential hyperthermia and low- dose rate brachytherapy, in order to test our hypothesis that concomitant therapy with both modalities given simultaneously will lead to the greater therapeutic benefit than conventional (sequential) therapy.

铁磁加热具有其他类型间隙加热的优点。 热疗是从肿瘤内部传递的， 全面加热整个肿瘤体积， 温度测定法 铁磁热疗的另一个独特优势是 镍铜合金将周围电磁波的能量 场转化为热能，但仅达到预设水平（例如，45 ℃）。 这种热量以可预测的方式扩散到正常的兔子肌肉中 组织，如我们实验室进行的初步实验所示。 我们还证明了联合收割机放射性碘（I-125） 用铁磁热籽晶，使电离辐射和 可以同时进行间质热疗。 我们的目标是 优化这两种治疗方式的组合，通过研究 几种物理和放射生物学因素对热的影响 I-125铁磁热疗的增强比 近距离放射治疗对兔移植性肿瘤的局部控制。 要检查的变量将是那些最有可能 临床影响：植入物内的I-125和热籽间距，以及 每种治疗方式的时间、剂量和分次。 我们还将 比较伴随与序贯高温和低温治疗的疗效， 剂量率近距离放射治疗，为了检验我们的假设， 同时给予两种方式的治疗将导致更大的 比常规（序贯）治疗更有疗效。