INCIDENTAL INFECTIOUS DISEASES AS COFACTORS

偶发传染病作为辅助因素

• 批准号: 3194499
• 负责人: NIELS C PEDERSEN
• 金额: $ 26.07万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-03-16 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3194499
• 关键词: Retroviridae; feline leukemia /sarcoma virus

Various cofactors are known to increase the rate of HIV infection and to cause asymptomatic seropositive individuals to more rapidly develop AIDs. The role of common infectious diseases as cofactors in enhancing both virus transmission and disease progression is of particular interest in human medicine but is difficult to study. Humans cannot be purposefully infected, pathogen free populations do not exist, and people cannot be put into sterile environments once they are infected. This aspect of HIV infection can be better studied using an appropriate animal model. Feline Immunodeficiency Virus (FIV) infection might provide such a model. Specific pathogen free (SPF) cats are available, experimental infections can be created, and various infectious disease exposing environments can be artificially recreated. We propose to study the role of secondary infections as cofactors in FIV transmission and disease progression in two way: 1) by exposing FIV-infected and non-infected specific pathogen free cats to a wide range of common feline pathogens by natural means, i.e. by contact exposure with conventional cats housed in the same rooms, and 2) by sequentially infecting FIV-infected and non- infected specific pathogen free cats with 7 common feline pathogens, feline herpesivirus, feline calicivirus, feline enteric coronavirus, Chlamydia psittaci, hemobartonella felis, Toxoplasma gondii, and feline leukemia virus. The purpose of the first study is to see if continuous exposure to many different secondary disease agents enhances the transmission of FIV between infected and susceptible cats or accelerates the progression from the asymptomatic to the AIDS-phase of illness. The aim of the second study is to see whether FIV infection in asymptomatic FIV-infected cats alters the normal clinical and immunologic manifestation of 7 common infectious diseases of cats, alters the carrier state that follow the clinical phase of these illnesses, affects the normal perturbations in lymphocyte blastogenesis that appear transiently during and after most common infectious processes. Conversely, we are interested in seeing whether coinfection of FIV infected cats with any of these agents alters the levels of FIV in their blood or accelerates their immunologic decline.

众所周知，各种辅助因素会增加艾滋病毒的感染率。 并使无症状的血清阳性个体更快地 发展艾滋病。常见传染病作为辅助因素的作用 在促进病毒传播和疾病进展方面， 对人类医学特别感兴趣，但很难研究。 人类不能被故意感染，没有病原体的人群 不存在，人类不能被置于无菌环境中 一旦他们被感染。艾滋病毒感染的这一方面可以更好 使用合适的动物模型进行研究。猫科动物免疫缺陷 病毒(FIV)感染可能提供了这样的模型。特定的 无病原体(SPF)猫是可用的，实验性感染可以 被创造和各种传染病暴露的环境 可以被人工重现。 我们建议研究继发感染作为辅助因素的作用。 FIV传播和疾病进展有两种方式：1)通过 暴露FIV感染和未感染特定病原体的猫 通过自然手段对一系列常见的猫科动物病原体产生影响，即 通过接触饲养在相同环境中的传统猫 房间，以及2)通过顺序感染FIV感染者和非感染者 用7只普通猫科动物感染无特定病原体的猫 病原体，猫疱疹病毒，猫杯状病毒，猫肠道 冠状病毒、鹦鹉热衣原体、猫血球菌属、弓形虫 贡地病毒和猫白血病病毒。第一项研究的目的 是为了看看是否持续接触到许多不同的二手烟 疾病制剂加强了FIV在感染人群之间的传播 和易受影响的猫，或者加速从 没有艾滋病症状的疾病阶段。第二个目标是 研究目的是观察在无症状的FIV感染中是否存在FIV感染 猫改变了正常的临床和免疫学表现 猫的7种常见传染病改变了携带者的状态 关注这些疾病的临床阶段，影响正常 短暂出现的淋巴细胞母细胞发生的扰动 在最常见的感染过程中和之后。相反，我们 有兴趣看看感染FIV的猫是否会同时感染 这些药物中的任何一种都会改变他们血液中的FIV水平 或者加速他们的免疫力下降。