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BIOLOGY OF THE PROLIFERATING CELL NUCLEAR ANTIGEN

BIOLOGY OF THE PROLIFERATING CELL NUCLEAR ANTIGEN
增殖细胞核抗原的生物学
批准号:
3198196
负责人:
RENATO Luigi BASERGA
金额:
$13.78万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-12-01 至 1995-11-30

项目摘要

项目成果

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中文摘要
翻译
增殖细胞核抗原(PCNA)是DNA的辅助因子
英文摘要
The Proliferating Cell Nuclear Antigen (PCNA) is the co-factor of DNA polymerase delta, a Key enzyme in cellular DNA synthesis. Is is required for DNA replication and cell cycle progression. Because of the important role that PCNA plays in proliferating cells and because of some unusual aspects in the structure and function of its gene, we propose to investigate the growth-regulation of the PCNA gene, how growth factors affect it and which trans-acting factors interact with its regulatory elements. This project's goal is a better understanding of the factors that regulate cell cycle progression at the G1/S boundary.
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  • 财政年份:
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  • 批准号:
    6641119
  • 项目类别:
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    7284862
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  • 财政年份:
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海外基金