BIOLOGY OF THE PROLIFERATING CELL NUCLEAR ANTIGEN

增殖细胞核抗原的生物学

• 批准号: 3198198
• 负责人: RENATO Luigi BASERGA
• 金额: $ 3.79万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-12-01 至 1995-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3198198
• 关键词: DNA binding protein; DNA directed DNA polymerase; DNA replication; cell growth regulation; genetic promoter element; genetic regulatory element; genetic transcription; messenger RNA; nucleic acid sequence; transcription factor

The Proliferating Cell Nuclear Antigen (PCNA) is the co-factor of DNA polymerase delta, a Key enzyme in cellular DNA synthesis. Is is required for DNA replication and cell cycle progression. Because of the important role that PCNA plays in proliferating cells and because of some unusual aspects in the structure and function of its gene, we propose to investigate the growth-regulation of the PCNA gene, how growth factors affect it and which trans-acting factors interact with its regulatory elements. This project's goal is a better understanding of the factors that regulate cell cycle progression at the G1/S boundary.

增殖细胞核抗原（PCNA）是DNA的辅因子 聚合酶δ，细胞DNA合成的关键酶。是必需的 DNA复制和细胞周期进程。因为重要的 PCNA在增殖细胞中的作用，由于一些不寻常的 在其基因的结构和功能方面，我们建议 研究PCNA基因的生长调节， 影响它，哪些反式作用因子与它的调节因子相互作用 元素该项目的目标是更好地了解 在G1/S边界调节细胞周期进程。