BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE

拟议的调查旨在确定一个群体的特征和区别 关于滥用药物作为歧视性刺激的性质。 重点将放在吲哚/苯乙胺的致幻剂上 类型包括麦角酸二乙胺(LSD)和2，5-二甲氧基-4- 甲基苯丙胺(DOM)。所有从行为上研究的药物也将 根据它们在5-羟色胺能和5-羟色胺能的结合特性进行检查 肾上腺素能受体。最初，结合将在5- HT1a。5-HT1B、5-HT1C和5-HT2亚型的5-羟色胺能受体和 在α和β肾上腺素能受体。 几乎所有滥用药物都能在动物身上承担刺激控制作用。 这一事实提供了一种敏感和信息丰富的方法来研究 习惯性选择的多种药物对非心绞痛的作用机制 人类的医疗用途。补充甄别方法，受体 结合技术提供了一个独特的机会来评估分子 作为特定行为效果基础的事件。因此，受体结合 并将并行进行行为实验。后者将 提供证据支持或反对某一给定的功能意义 受体位置。拟议研究的长期目标是 了解这些复杂的行为影响 生物化学术语，从而便于合理的临床干预。

The proposed investigation seeks to characterize and distinguish a group of drugs of abuse in terms of their properties as discriminative stimuli. Emphasis will be upon hallucinogens of the indoleamine/phenethylamine type including lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4- methylamphetamine (DOM). All drugs studied behaviorally also will be examined in terms of their binding characteristics at serotonergic and adrenergic receptors. initially, binding will be quantitated at the 5- HT1A. 5-HT1B, 5-HT1C, and 5-HT2 subtypes of the serotonergic receptor and at the alpha and beta adrenergic receptors. Nearly all drugs of abuse are able to assume stimulus control in animals. This fact provides a sensitive and informative approach to the study of the mechanisms of action of a variety of drugs habitually chosen for non- medical use by humans. Complementing discrimination methods, receptor binding techniques provide a unique opportunity to assess the molecular events which underlie specific behavioral effects. Thus, receptor binding and behavioral experiments will be conducted in parallel. The latter will provide evidence either for or against functional significance of a given receptor site. A long-term objective of the proposed research is to achieve an understanding of these complex behavioral effects in biochemical terms and thus to facilitate rational clinical intervention.