BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE

行为的

• 批准号: 3207879
• 负责人: JERROLD Clyne WINTER
• 金额: $ 16.11万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3207879
• 关键词: 2,5 dimethoxy 4 methylamphetamine; adrenergic receptor; drug abuse; drug addiction antagonist; drug metabolism; drug receptors; ethology; laboratory rat; lysergic acid diethylamide; psychopharmacology; psychotomimetic drug; radiotracer; receptor binding; scintillation spectrometry; serotonin receptor; stimulus /response

The proposed investigation seeks to characterize and distinguish a group of drugs of abuse in terms of their properties as discriminative stimuli. Emphasis will be upon hallucinogens of the indoleamine/phenethylamine type including lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4- methylamphetamine (DOM). All drugs studied behaviorally also will be examined in terms of their binding characteristics at serotonergic and adrenergic receptors. initially, binding will be quantitated at the 5- HT1A. 5-HT1B, 5-HT1C, and 5-HT2 subtypes of the serotonergic receptor and at the alpha and beta adrenergic receptors. Nearly all drugs of abuse are able to assume stimulus control in animals. This fact provides a sensitive and informative approach to the study of the mechanisms of action of a variety of drugs habitually chosen for non- medical use by humans. Complementing discrimination methods, receptor binding techniques provide a unique opportunity to assess the molecular events which underlie specific behavioral effects. Thus, receptor binding and behavioral experiments will be conducted in parallel. The latter will provide evidence either for or against functional significance of a given receptor site. A long-term objective of the proposed research is to achieve an understanding of these complex behavioral effects in biochemical terms and thus to facilitate rational clinical intervention.

拟议的调查旨在描述和区分一个群体， 滥用药物作为歧视性刺激的特性。 重点将放在致幻剂吲哚胺/苯乙胺 麦角酸二乙基酰胺（LSD）和2，5-二甲氧基-4- 甲基苯丙胺（DOM）。所有行为学研究的药物也将 检查了它们的结合特性， 肾上腺素能受体最初，结合将在5- HT1A。肾上腺素能受体的5-HT 1B、5-HT 1C和5-HT 2亚型， 肾上腺素能受体的反应 几乎所有的滥用药物都能在动物身上产生刺激控制。 这一事实提供了一个敏感和翔实的方法来研究 各种药物的作用机制，通常选择非- 人类的医疗用途。补充鉴别方法，受体 结合技术提供了一个独特的机会，以评估分子 特定行为效应背后的事件。因此， 行为实验将同时进行。后者将 提供支持或反对给定功能重要性的证据 受体部位拟议研究的长期目标是 了解这些复杂的行为效应， 生物化学术语，从而促进合理的临床干预。