BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
批准号:
2116740
负责人:
JERROLD Clyne WINTER
金额:
$21.82万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-01-01 至 1996-12-31
关键词:
2,5 dimethoxy 4 methylamphetamine adenylate cyclase apomorphine behavior test drug addiction antagonist drug receptors enzyme activity hallucinogens indoleamine laboratory rat lipid metabolism lysergic acid diethylamide neuropharmacology operant conditionings phenylethylamines phosphatidylinositols piperazines psychopharmacology receptor binding second messengers serotonin receptor
中文摘要
拟议的调查旨在描述和区分
英文摘要
The proposed investigation seeks to characterize and to distinguish a
group of serotonergic drugs of abuse in terms of their properties as
discriminative stimuli. Emphasis will be upon hallucinogens of the
indole/phenethylamine type including lysergic acid diethylamide (LSD] and
2,5-dimethoxy-4-methyl-amphetamine (DOM). In addition, rats will be
trained with chlorophenylpiperazine [MCPP], a drug widely used as a probe
of serotonergic activity in humans. MCPP-trained subjects will be
particularly useful in assessing the functional importance of 5-HT1C
receptors. In order to lay a groundwork for the biochemical basis for
their stimulus effects, these same drugs will be characterized with
respect to their affinities for serotonergic and other selected receptors
in the central nervous system and with respect to their ability to alter
second messenger systems.
Taken together, the use of powerful methods for the assessment of in vivo
efficacy (drug discrimination], of in vitro efficacy [stimulation or
suppression of second messenger formation], and of affinities for specific
receptors (radioligand binding] will provide new understanding of the mode
of action of serotonergic drugs, especially those subject to abuse. Thus,
biochemical and behavioral experiments will be conducted in parallel. A
long-term objective of the proposed research is to achieve an
understanding in biochemical terms of these complex behavioral events in
animals and thus to facilitate rational treatment interventions for
humans.
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会议论文
Behavioral & Pharmacological Analysis of Drugs of Abuse
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批准号:6778352
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项目类别:
-
资助金额:$35.33万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:3207876
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项目类别:
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资助金额:$8.05万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL AND PHARMACOLOGIC ANALYSIS OF DRUG OF ABUSE
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批准号:2395832
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项目类别:
-
资助金额:$21.91万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:3207879
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项目类别:
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资助金额:$16.11万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
Behavioral & Pharmacological Analysis of Drugs of Abuse
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批准号:6515364
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项目类别:
-
资助金额:$35.1万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:3207873
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项目类别:
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资助金额:$13.42万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:3207878
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项目类别:
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资助金额:$15.33万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL AND PHARMACOLOGIC ANALYSIS OF DRUG OF ABUSE
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批准号:2713059
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项目类别:
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资助金额:$21.99万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
Behavioral and Pharmacological Analysis of Drugs of Abuse
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批准号:7640034
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项目类别:
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资助金额:$28.76万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
Behavioral & Pharmacological Analysis of Drugs of Abuse
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批准号:6911502
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项目类别:
-
资助金额:$35.33万
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财政年份:1985
-
负责人:JERROLD Clyne WINTER
-
依托单位:
BEHAVIORAL AND PHARMACOLOGIC ANALYSIS OF DRUG OF ABUSE
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批准号:2897695
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项目类别:
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资助金额:$22.65万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:3207877
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项目类别:
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资助金额:$9.2万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL AND PHARMACOLOGIC ANALYSIS OF DRUG OF ABUSE
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批准号:6175201
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项目类别:
-
资助金额:$23.33万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
Behavioral & Pharmacological Analysis of Drugs of Abuse
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批准号:6606143
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项目类别:
-
资助金额:$35.33万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:3207870
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项目类别:
-
资助金额:$8.33万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
Behavioral & Pharmacological Analysis of Drugs of Abuse
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批准号:6433786
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项目类别:
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资助金额:$34.88万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:2116741
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项目类别:
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资助金额:$19.72万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
BEHAVIORAL & PHARMACOLOGICAL ANALYSIS OF DRUGS OF ABUSE
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批准号:2116742
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项目类别:
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资助金额:$20.51万
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财政年份:1985
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负责人:JERROLD Clyne WINTER
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依托单位:
海外基金