NEUROBEHAVIORAL FACTORS IN BLACK MEN AT RISK FOR AIDS

这项为期3年的横断面研究的目的是调查 HIV-1感染对黑人男性神经行为的影响 艾滋病 要研究的主要高风险类别是HIV-1 血清状况、药物使用和同性恋/双性恋取向（H/B），以及 相关风险行为。 这项研究旨在实现以下五个目标 目标：1.标准化神经心理学（NP）和脑成像 (BI)血清阴性（SN）黑人非药物使用者（D-）中的参数; 2.到 估计性取向和行为对NP的可能影响 和SN黑色D-中的BI结局; 3.估计可能的独立 HIV-1血清状态、药物使用和智商对NP & BI的交互作用 艾滋病无症状（ASP）的H/B黑人的结局; 4.到 估计艾滋病相关症状对NP和BI的可能影响 H/B血清阳性（SSP）黑D-的结果;以及，5.以确定是否 上述任何影响都是由社会心理因素（PS）介导的 将招募两组黑人男性（18-50岁）。 队列1 （父母队列）将包括750名黑人男性的样本， 根据HIV-1血清状态、吸毒和性取向分为六类 组：100名同性恋/双性恋ASP/D+，100名同性恋/双性恋SN/D+，100名同性恋/双性恋 ASP/D-，50例同性恋/双性恋SSP，200例同性恋/双性恋SN/D-（同性恋比较），以及 200名异性SN/D-（异性比较）。 父队列将 通过NP和PS措施的综合测试，以及基本的 人口统计、吸毒史和性行为信息将被 得到了 400个比较SB的样本将作为 标准化样本，以建立适当的Np和BI标准（目标1）， 并测试性取向和行为对NP & BI的影响 结果（目标2）心理社会假设将在整个测试 sample. 队列2（巢式队列）将随机抽取250例H/B受试者 并将通过全面的神经成像进行测试 测量包括MRI和SPECT，用于检测NP、PS和BI 5个同性恋/双性恋群体之间的差异（目标3、4和5）。 是 预计这项研究的结果应该提供一个强有力的实证 未来研究神经行为后果的基金会 HIV-1感染的黑人男性。

The purpose of this 3-year cross-sectional study is to investigate the neurobehavioral effects of HIV-1 infection in black males at risk for AIDS. The primary high-risk categories to be studied are HIV-1 serostatus, drug use, and homosexual/bisexual orientation (H/B) and related risk behaviors. The study seeks to achieve the following five aims: 1. to standardize the neuropsychological (NP) and brain imaging (BI) parameters in seronegative (SN) black non-drug users (D-); 2. to estimate the possible effects of sexual orientation and behavior on NP and BI outcomes in SN black D-; 3. To estimate the possible independent and interaction effects of HIV-1 serostatus, drug use and IQ on NP & BI outcomes in H/B blacks who are asymptomatic (ASP) for AIDS; 4. to estimate the possible effects of AIDS-related symptoms on NP & BI outcomes in H/B seropositive (SSP) black D-; and, 5. to determine whether any of the effects noted above are mediated by psychosocial (PS) factors Two cohorts of black males (18-50 yrs) will be recruited. Cohort 1 (Parent cohort) will comprise a sample of 750 black males that will be classified by HIV-1 serostatus, drug use and sexual orientation into six groups: 100 gay/bisexual ASP/D+, 100 gay/bisexual SN/D+, 100 gay/bisexual ASP/D-, 50 gay/bisexual SSP, 200 gay/bisexual SN/D- (gay comparison), and 200 heterosexual SN/D- (heterosexual comparison). The parent cohort will be tested with a comprehensive battery of NP and PS measures, and basic demographic, history of drug use and sexual practices information will be obtained. The sample of 400 comparison SB will serve as the standardization sample to establish appropriate Np & BI norms (Aim 1), and to test for the effects of sexual orientation and behavior on NP & BI outcomes (Aim 2) The psychosocial hypotheses will be tested on the entire sample. Cohort 2 (Nested cohort) will be a random sample of 250 H/B subjects from the parent cohort and will be tested with comprehensive neuroimaging measures including MRI and SPECT, and used to test for NP, PS and BI differences between the 5 gay/bisexual groups (Aims 3, 4 & 5). It is expected that the results of this study should provide a strong empirical foundation for future research on the neurobehavioral consequences of HIV-1 infection in black men.