NEUROBEHAVIORAL FACTORS IN BLACK MEN AT RISK FOR AIDS

这项为期3年的横断面研究的目的是调查 HIV-1感染对易患艾滋病的黑人男性的神经行为影响 艾滋病。要研究的主要高危类别是艾滋病毒-1 血清状况、吸毒和同性恋/双性恋取向(H/B)和 相关危险行为。这项研究旨在实现以下五个方面 目的：1.规范神经心理学(NP)和脑成像 (Bi)血清阴性(SN)黑人非吸毒者(D-)的参数； 估计性取向和性行为对NP的可能影响 和在SN BLACK D中的BI结果；3.估计可能的独立 HIV-1血清状态、药物使用和智商对NP和BI的交互作用 无艾滋病症状(ASP)的H/B黑人的结果；4.到 估计艾滋病相关症状对NP和BI的可能影响 H/B血清阳性(SSP)黑人D-的结果；以及，5.确定 上面提到的任何影响都是由心理社会(PS)因素介导的 将招募两批黑人男性(18-50岁)。队列1 (父母队列)将包括750名黑人男性样本，这将是 按HIV-1血清状态、药物使用和性取向分为六类 群体：100名男同性恋/双性恋ASP/D+，100名男同性恋/双性恋SN/D+，100名男同性恋/双性恋 ASP/D-，50个同性恋/双性恋SSP，200个同性恋/双性恋SN/D-(同性恋比较)，以及 200个异性恋SN/D-(异性比较)。父代队列将 使用一套全面的NP和PS措施进行测试，以及基本 人口统计、吸毒史和性行为信息将 获得。400个比对的样本SB将作为 标准样本，以建立适当的NP和BI标准(目标1)， 并测验性取向和性行为对NP和BI的影响 结果(目标2)心理社会假说将在总体上得到检验 样本。 队列2(嵌套队列)将是250名H/B受试者的随机样本 并将通过全面的神经成像进行测试 包括MRI和SPECT，用于检测NP、PS和BI 5个同性恋/双性恋群体之间的差异(目标3、4和5)。它是 预计这项研究的结果应该会提供强有力的实证 为未来研究高血压病患者神经行为后果奠定基础 黑人男性感染HIV-1病毒。

The purpose of this 3-year cross-sectional study is to investigate the neurobehavioral effects of HIV-1 infection in black males at risk for AIDS. The primary high-risk categories to be studied are HIV-1 serostatus, drug use, and homosexual/bisexual orientation (H/B) and related risk behaviors. The study seeks to achieve the following five aims: 1. to standardize the neuropsychological (NP) and brain imaging (BI) parameters in seronegative (SN) black non-drug users (D-); 2. to estimate the possible effects of sexual orientation and behavior on NP and BI outcomes in SN black D-; 3. To estimate the possible independent and interaction effects of HIV-1 serostatus, drug use and IQ on NP & BI outcomes in H/B blacks who are asymptomatic (ASP) for AIDS; 4. to estimate the possible effects of AIDS-related symptoms on NP & BI outcomes in H/B seropositive (SSP) black D-; and, 5. to determine whether any of the effects noted above are mediated by psychosocial (PS) factors Two cohorts of black males (18-50 yrs) will be recruited. Cohort 1 (Parent cohort) will comprise a sample of 750 black males that will be classified by HIV-1 serostatus, drug use and sexual orientation into six groups: 100 gay/bisexual ASP/D+, 100 gay/bisexual SN/D+, 100 gay/bisexual ASP/D-, 50 gay/bisexual SSP, 200 gay/bisexual SN/D- (gay comparison), and 200 heterosexual SN/D- (heterosexual comparison). The parent cohort will be tested with a comprehensive battery of NP and PS measures, and basic demographic, history of drug use and sexual practices information will be obtained. The sample of 400 comparison SB will serve as the standardization sample to establish appropriate Np & BI norms (Aim 1), and to test for the effects of sexual orientation and behavior on NP & BI outcomes (Aim 2) The psychosocial hypotheses will be tested on the entire sample. Cohort 2 (Nested cohort) will be a random sample of 250 H/B subjects from the parent cohort and will be tested with comprehensive neuroimaging measures including MRI and SPECT, and used to test for NP, PS and BI differences between the 5 gay/bisexual groups (Aims 3, 4 & 5). It is expected that the results of this study should provide a strong empirical foundation for future research on the neurobehavioral consequences of HIV-1 infection in black men.