CAFFEINE'S EFFECTS ON SMOKING AND NICOTINE WITHDRAWAL

咖啡因对吸烟和尼古丁戒断的影响

• 批准号: 3213604
• 负责人: James D. Lane
• 金额: $ 25.16万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3213604
• 关键词: adult human (21+); association learning; caffeine; carbon monoxide; cardiovascular function; catecholamines; cognition; drug addiction; drug withdrawal; ethology; high performance liquid chromatography; human subject; male; neuroendocrine system; nicotine; performance; racial /ethnic difference; smoking cessation; statistics /biometry; tobacco abuse; urine

Cigarette smoking is commonly linked to the consumption of caffeinated beverages, especially coffee. Epidemiological studies suggest strong correlations between number of cigarettes smoked and quantity of coffee consumed daily. Furthermore, the act of coffee-drinking can be a strong stimulus for smoking in many individuals. The long-term objective of this research program is to determine whether the association of coffee or caffeine consumption with smoking contributes significantly to the adverse health consequences or addictive potential of smoking. The application considers three different areas in which coffee drinking could contribute to the risks of smoking. First, caffeine consumption could potentiate the sympathomimetic effects of nicotine and increase their pathogenicity. Caffeine is known to potentiate other sympathetically mediated responses. A laboratory study will examine the dose-related effects of caffeine pretreatment on sympathetically mediated cardiovascular and neuroendocrine responses to a controlled dose of nicotine in cigarette smoke. Second, the consumption of caffeine or coffee could affect a smoker's ad lib intake of cigarette smoke and nicotine through pharmacological or behavioral mechanisms. A laboratory study will examine the separate and combined effects of caffeine administration and coffee-drinking behaviors on short-term smoking behavior and nicotine intake. A related study will examine the effects of caffeinated vs. dicaffeinated coffee consumption on ad lib smoke and nicotine intake during week-long periods of normal activity. Third, caffeine consumption could make smoking cessation more difficult and increase the likelihood of relapse by adding to or intensifying the symptoms of tobacco abstinence or by altering the cognitive and performance deficits that appear during abstinence. One study will examine tbe effects of caffeinated vs. decaffeinated coffee on withdrawal symptoms and craving during 4-day periods of experimental smoking abstinence. A related laboratory study will examine dose-related caffeine effects on the performance decrements associated with acute smoking deprivation. Each of the five studies will also explore potential racial or ethnic differences in caffeine/coffee effects and smoking behaviors by the inclusion and direct comparison of groups of White and Black subjects in each protocol. Together, these five proposed studies should provide new insights into cigarette smoking behavior and its health consequences. Furthermore, an understanding of the effects of caffeine and coffee drinking on smoking behavior should yield practical suggestions that will enhance clinical efforts directed at smoking cessation.

吸烟通常与摄入含咖啡因的饮料有关 饮料，尤其是咖啡。 流行病学研究表明强烈 吸烟数量与咖啡量之间的相关性 每天消耗。 此外，喝咖啡的行为可能会产生强烈的影响。 刺激许多人吸烟。 长期目标 这项研究计划是为了确定咖啡是否与咖啡有关 或吸烟时摄入咖啡因会显着导致 吸烟的不良健康后果或成瘾潜力。 该应用程序考虑了咖啡饮用的三个不同领域 可能会增加吸烟的风险。 一、咖啡因摄入量 可以增强尼古丁的拟交感神经作用并增加 它们的致病性。 众所周知，咖啡因可以增强其他功能 同情介导的反应。 实验室研究将检查 咖啡因预处理对交感神经的剂量相关影响 介导心血管和神经内分泌反应 香烟烟雾中尼古丁的剂量。 二、消费 咖啡因或咖啡可能会影响吸烟者随意吸烟的量 通过药理学或行为机制产生烟雾和尼古丁。 一个 实验室研究将检查单独和综合的影响 咖啡因管理和短期咖啡饮用行为 吸烟行为和尼古丁摄入量。 一项相关研究将检验 饮用含咖啡因与含双咖啡因的咖啡对即兴发挥的影响 为期一周的正常活动期间的烟雾和尼古丁摄入量。 第三，摄入咖啡因可能会使戒烟变得更加困难 并通过增加或加强治疗来增加复发的可能性 戒烟的症状或通过改变认知和 禁欲期间出现的表现缺陷。 一项研究将 检查含咖啡因咖啡与不含咖啡因咖啡的影响 4天的实验期间出现戒断症状和渴望 戒烟。 相关的实验室研究将检查 剂量相关的咖啡因对相关性能下降的影响 严重戒烟。 这五项研究中的每一项也将 探索咖啡因/咖啡的潜在种族或民族差异 通过纳入和直接比较来了解影响和吸烟行为 每个协议中的白人和黑人受试者组。 总之，这五项拟议的研究应该提供新的见解 吸烟行为及其健康后果。 此外，一个 了解咖啡因和饮用咖啡对吸烟的影响 行为应该产生切实可行的建议，从而增强临床效果 旨在戒烟的努力。