Caffeine and Glucose Regulation

咖啡因和血糖调节

• 批准号: 7066110
• 负责人: James D. Lane
• 金额: $ 35.34万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7066110
• 关键词: blood glucose; body physical activity; caffeine; carbohydrates; cardiovascular disorder risk; clinical research; diabetes risk; drug related diabetes mellitus; glucose metabolism; glucose tolerance; human subject; hyperglycemia; hyperinsulinism; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; patient monitoring device; phlebotomy

DESCRIPTION (provided by applicant): Caffeine has widespread effects in the 90 percent of US adults who consume it daily. Recent research in our laboratory indicates that caffeine has disruptive effects on glucose metabolism that may seriously impair glycemic control in type 2 diabetes and aggravate insulin resistance in pre-diabetic individuals. We propose 4 studies to determine the nature and extent of caffeine's effects and their potential importance to diabetes. A replication and extension of our preliminary study will examine the effects of a controlled dose of caffeine on fasting glucose and insulin and responses to the oral glucose tolerance test (OGTT) to determine whether caffeine aggravates hyperglycemic and hyperinsulinemic responses in type 2 diabetes patients. We will test a variety of clinical and physiological factors that could account for individual differences in caffeine's effects, to identify patients at greatest risk of impairment and to elucidate potential mechanisms of action. A similar study will determine caffeine's effects on glucose metabolism in subjects who are currently "pre-diabetic," but at risk of developing clinical diabetes. Confirming that caffeine increases insulin resistance and may elicit hyperglycemia in this group would establish caffeine as a factor that could aggravate and contribute to the metabolic processes that lead to the development of diabetes in this high-risk group. A third study will extend our laboratory findings into the natural environment and explore the use of continuous glucose monitoring system (CGMS) methodologies to determine the effects of caffeine consumption on blood glucose during normal daily activities. These ambulatory measurements will complement the controlled laboratory studies and establish the ecological importance of these effects. Together these studies will establish a foundation of evidence regarding caffeine's effects on glucose metabolism and their importance to clinical glucose management in type 2 diabetes. This foundation will support later studies of mechanism as well as clinical intervention trials.

描述(申请人提供)：咖啡因在90%的美国成年人中有广泛的影响，他们每天都会摄入咖啡因。我们实验室最近的研究表明，咖啡因对糖代谢有干扰作用，可能会严重损害2型糖尿病患者的血糖控制，并加剧糖尿病前期患者的胰岛素抵抗。我们建议进行4项研究，以确定咖啡因的影响的性质和程度，以及它们对糖尿病的潜在重要性。我们的初步研究的复制和扩展将检查受控剂量的咖啡因对空腹血糖和胰岛素的影响以及对口服葡萄糖耐量试验(OGTT)的反应，以确定咖啡因是否会加剧2型糖尿病患者的高血糖和高胰岛素反应。我们将测试各种临床和生理因素，这些因素可以解释咖啡因影响的个体差异，以确定最有可能受到损害的患者，并阐明潜在的作用机制。 一项类似的研究将确定咖啡因对目前“糖尿病前期”但有可能发展为临床糖尿病的受试者的葡萄糖代谢的影响。证实咖啡因会增加胰岛素抵抗，并可能在这一组中引发高血糖，这将确立咖啡因是一个因素，可能会加剧并促进导致这一高危组糖尿病发展的代谢过程。 第三项研究将把我们的实验室发现扩展到自然环境中，并探索使用连续血糖监测系统(CGMS)方法来确定在正常日常活动中摄入咖啡因对血糖的影响。这些动态测量将补充受控的实验室研究，并确定这些影响的生态重要性。 总之，这些研究将为咖啡因对葡萄糖代谢的影响及其对2型糖尿病临床血糖管理的重要性奠定证据基础。这一基础将为以后的机制研究和临床干预试验提供支持。