DENTAL AND OROFACIAL PAIN: BRAIN STEM MECHANISMS

牙齿和口面部疼痛：脑干机制

• 批准号: 3219144
• 负责人: BARRY J. SESSLE
• 金额: $ 8.89万
• 依托单位: UNIVERSITY OF TORONTO
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1986-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219144
• 关键词: antidromic impulse; brain stem; cutaneous sensory nerve; electrophysiology; neural information processing; neural plasticity; neurochemistry; norepinephrine; oral facial pain; pain; serotonin; single cell analysis; trigeminal neuralgia; visceral afferent nerve

The overall objective of the research of program is the clarification of trigeminal nociceptive mechanisms, especially in the brainstem, related to acute and chronic pain conditions that afflict the face and mouth. Our recent NIH-supported studies, which have produced 10 papers and 7 abstracts in 1981 and 1982, have helped provide some of the insights into the brainstem mechanisms involved in dental and facial pain in particular. Major gaps or uncertainties in our knowledge however still exist in the neural mechanisms underlying dental, joint and muscle pain especially and in the processes associated with pain conditions that may be related to muscle dysfunction (e.g. TMJ or myofascial pain dysfunction syndrome) or to sensory loss (e.g. painful sensory neuropathies, neuralgias, causalgias). We will use our expertise and experience gained over the last 18 years with the trigeminal system of the cat and monkey and continue to examine functionally identified single noticeptive and nonnociceptive neurons recorded electrophysiologically in the trigeminal spinal tract nucleus of the cat. In particular, we now propose to determine which types of neurons relay joint and musle nociceptive information and to study the response properties and convergent patterns seen in these neurons with stimulation of muscle, joint and other orofacial afferents (Aim i); to determine if these responses can be modulated by other sensory inputs and by descending influences from brainstem, cortex and thalamic sites implicated in pain and analgesia and gain insights into the underlying neurochemical mechanisms by studying the effects on the modulatory influences of antagonists to the possible neurochemicals involved (Aim ii); and continue to investigate the effects of sensory loss on the functional organization of these neurons by delineating further the changes in their functional properties that we have shown to occur with tooth pulp extirpation and comparing them with likely changes that may be induced by deafferentation of other orofacial structures or interruption of the modulatory interaction that has been demonstrated between different components of the nucleus (Aim iii). We anticipate that our findings will lead to future studies in kittens and chronic recording investigations in adult animals to examine maturational and behavioral changes that may be associated with orofacial sensory alterations.

程序研究的总体目标是澄清 三叉神经伤害性机制，特别是在脑干，与 急性和慢性疼痛的条件，折磨的脸和嘴。 我们 最近NIH支持的研究，产生了10篇论文和7篇摘要 在1981年和1982年，帮助提供了一些见解， 特别是涉及牙齿和面部疼痛的脑干机制。 然而，在我们的知识中仍然存在重大差距或不确定性， 尤其是牙齿、关节和肌肉疼痛的神经机制， 在与可能与疼痛有关的疼痛状况相关的过程中 肌肉功能障碍（例如TMJ或肌筋膜疼痛功能障碍综合征）或 感觉丧失（例如疼痛性感觉神经病、神经痛、头痛）。 我们将利用我们在过去18年中获得的专业知识和经验， 猫和猴子的三叉神经系统， 功能鉴定的单一伤害感受和非伤害感受神经元 记录在三叉神经脊束核的电生理 特别是，我们现在建议确定哪些类型的神经元 传递关节和肌肉伤害性信息，并研究反应 在这些神经元中观察到的特性和会聚模式 肌肉，关节和其他口面传入（目的i）;以确定是否 这些反应可以通过其他感觉输入和下行 脑干、皮质和丘脑部位与疼痛有关， 镇痛和获得深入了解潜在的神经化学机制， 研究了拮抗剂对调节作用的影响， 可能涉及的神经化学物质（目标ii）;并继续研究 感觉丧失对这些神经元功能组织的影响， 进一步描绘了它们的功能特性的变化， 显示发生牙髓摘除，并比较他们可能与 可能由其他口面神经传入阻滞引起的变化 结构或中断的调节相互作用， 核的不同组成部分之间的证明（目的iii）。 我们 我希望我们的发现将引导未来对小猫的研究， 在成年动物中进行慢性记录研究，以检查成熟 以及可能与口面感觉有关的行为变化 改变。