BEHAVIORAL EFFECTS AND ABUSE OF DRUGS: ANTIHISTAMINES

组胺H1拮抗剂是最常用的药物之一 当代社会中的毒品，并被滥用与 某些药物依赖人群的阿片类药物。我们之前的工作 已经表明，典型的H1拮抗剂具有显著的效果 在进度控制行为上，可以通过 多巴胺拮抗剂氟哌啶醇。这次会议的一个主要焦点是 拟议的研究是进一步评估多巴胺的作用- H1受体拮抗剂在行为效应中的相关作用：1) H1受体拮抗剂与选择性受体拮抗剂的作用比较 D_1和D_2激动剂；2)研究 H1拮抗剂可被选择性的D1和D2拮抗剂改变。 我们之前已经发现，选定的H1拮抗剂可以 维持松鼠猴子的持续服药行为。一个 该项目的第二个重点是通过以下方式扩展这些发现：1) 浅谈吸毒幼稚人群自我管理的发展 受试者，2)自我给药的效果评价 对其他正在进行的行为的敌手，以及3)调查 H1拮抗剂的增强作用可通过以下方式改变 多巴胺D1和D2拮抗剂。我们正在进行的研究表明 H1拮抗剂可以增强大鼠的行为效应 可卡因和咖啡因。拟议研究的第三个重点是 通过系统地确定H1如何 拮抗剂改变了增强和其他行为效应 可卡因、咖啡因和尼古丁。该计划的最终目标是 建议的研究是继续我们对行为的评估 阿片类药物单独及与组胺H1合用的作用 对抗者。我们将评估这些药物之间的相互作用 通过确定H1拮抗者如何修改加强 以及五唑碱和其他阿片类药物的其他行为影响。 总的来说，拟议的研究将提供所需的信息。 关于药理和环境因素介导的 组胺H1拮抗剂单独和联合给药的行为效应 与其他常用药物联合使用。

Histamine H1 antagonists are among the most frequently used drugs in contemporary society and are abused in combination with opioids by certain drug-dependent populations. Our previous work has shown that prototypical H1 antagonists have striking effects on schedule-controlled behavior that can be attenuated by the dopamine antagonist haloperidol. One major focus of the proposed research is to evaluate further the role of dopamine- related actions in the behavioral effects of H1 antagonists by: 1) comparing the effects of H1 antagonists with those of selective D1 and D2 agonists and 2) studying how the behavioral effects of H1 antagonists are altered by selective D1 and D2 antagonists. We previously have found that selected H1 antagonists can maintain persistent drug-taking behavior in squirrel monkeys. A second focus of this project is to extend these findings by: 1) studying the development of self-administration in drug-naive subjects, 2) evaluating the effects of self-administered H1 antagonists on other ongoing behavior, and 3) investigating how the reinforcing effects of H1 antagonists are modified by dopamine D1 and D2 antagonists. Our ongoing research indicates that H1 antagonists can potentiate the behavioral effects of cocaine and caffeine. A third focus of the proposed research is to extend these studies by systematically determining how H1 antagonists modify the reinforcing and other behavioral effects of cocaine, caffeine, and nicotine. The final objective of the proposed research is to continue our evaluation of the behavioral effects of opioids alone and in combination with histamine H1 antagonists. We will assess interactions between these drug classes by determining how H1 antagonists modify the reinforcing and other behavioral effects of pentazocine and other opioids. Overall, the proposed research will provide needed information about pharmacological and environmental factors mediating the behavioral effects of histamine H1 antagonists alone and in combination with other commonly used drugs.