BEHAVIORAL EFFECTS AND ABUSE OF DRUGS: ANTIHISTAMINES

组胺H1拮抗剂是最常用的 药物在当代社会中的滥用， 某些药物依赖人群使用阿片类药物。 我们以前的工作 已经表明原型H1拮抗剂具有显著的效果， 在时间表控制的行为，可以削弱 多巴胺拮抗剂氟哌啶醇。 的一个主要重点 这项研究的目的是进一步评估多巴胺的作用， H1拮抗剂行为效应的相关作用：1） 比较H1拮抗剂与选择性 D1和D2激动剂和2）研究如何行为的影响， H1拮抗剂被选择性D1和D2拮抗剂改变。 我们以前已经发现，选择的H1拮抗剂可以 保持松鼠猴的持续吸毒行为。 一 本项目的第二个重点是通过以下方式扩展这些发现：1） 研究未吸毒者自我给药的发展 受试者，2）评估自我管理的H1的效果 拮抗剂对其他正在进行的行为，和3）调查如何 H1拮抗剂的增强作用通过以下方式改变： 多巴胺D1和D2拮抗剂。 我们正在进行的研究表明 H1拮抗剂可以增强 可卡因和咖啡因 拟议研究的第三个重点是 通过系统地确定H1 拮抗剂改变了增强和其他行为的影响， 可卡因咖啡因和尼古丁 的最终目标 建议的研究是继续我们的评估行为， 阿片类药物单独使用和与组胺H1联合使用的作用 对手。 我们将评估这些药物之间的相互作用 通过确定H1拮抗剂如何修饰增强的 以及喷他佐辛和其他阿片类药物的其他行为影响。 总体而言，拟议的研究将提供所需的信息 关于药理学和环境因素介导的 单独使用组胺H1拮抗剂和 与其他常用药物联合使用。

Histamine H1 antagonists are among the most frequently used drugs in contemporary society and are abused in combination with opioids by certain drug-dependent populations. Our previous work has shown that prototypical H1 antagonists have striking effects on schedule-controlled behavior that can be attenuated by the dopamine antagonist haloperidol. One major focus of the proposed research is to evaluate further the role of dopamine- related actions in the behavioral effects of H1 antagonists by: 1) comparing the effects of H1 antagonists with those of selective D1 and D2 agonists and 2) studying how the behavioral effects of H1 antagonists are altered by selective D1 and D2 antagonists. We previously have found that selected H1 antagonists can maintain persistent drug-taking behavior in squirrel monkeys. A second focus of this project is to extend these findings by: 1) studying the development of self-administration in drug-naive subjects, 2) evaluating the effects of self-administered H1 antagonists on other ongoing behavior, and 3) investigating how the reinforcing effects of H1 antagonists are modified by dopamine D1 and D2 antagonists. Our ongoing research indicates that H1 antagonists can potentiate the behavioral effects of cocaine and caffeine. A third focus of the proposed research is to extend these studies by systematically determining how H1 antagonists modify the reinforcing and other behavioral effects of cocaine, caffeine, and nicotine. The final objective of the proposed research is to continue our evaluation of the behavioral effects of opioids alone and in combination with histamine H1 antagonists. We will assess interactions between these drug classes by determining how H1 antagonists modify the reinforcing and other behavioral effects of pentazocine and other opioids. Overall, the proposed research will provide needed information about pharmacological and environmental factors mediating the behavioral effects of histamine H1 antagonists alone and in combination with other commonly used drugs.