NASAL ANTIHISTAMINES & ALLERGIC RHINITIS INDUCED SLEEP DISTURBANCES

过敏性鼻炎的主要表现之一是充血。鼻塞会使患者容易出现睡眠呼吸暂停和微觉醒。这种睡眠障碍会导致白天昏昏欲睡和疲劳。鼻腔类固醇的使用在客观上和主观上都有效地减少了充血。目前，还没有研究表明鼻腔阻力、睡眠唤醒和日间疲劳与鼻腔类固醇激素有关。这项研究的主要目的是证明鼻腔类固醇可以减少充血，从而减少睡眠干扰，减少睡眠干扰将减少白天的疲劳和嗜睡。常年性变应性鼻炎的28名候选人将被选中参加。他们必须有鼻塞和睡眠障碍的主观发现，并伴随着白天的疲劳。这项研究将是一项交叉、双盲、安慰剂对照研究，为期八周。每个参与者都将开始为期四周的研究活动阶段，并与研究的另一组交叉，为期四周。程序包括病史、全面的身体检查、鼻炎严重程度问卷、刺激性过敏皮肤测试、睡眠功能障碍量表(Hoddes 1978)和关于睡眠、白天疲劳和鼻部症状的每日日记。

One of the main manifestations of allergic rhinitis is congestion. Nasal congestion can predispose the individual to sleep apnea and microarousals. This sleep disturbance can result in daytime somnolence and fatigue. The use of nasal steroids has been effective at reducing congestion, both objectively and subjectively. Presently, no study is available that shows objective decrease in nasal resistance, sleep arousals, and daytime fatigue in association with nasal steroids. The key objectives of this study are to demonstrate that nasal steroids can decrease congestion resulting in less sleep disturbances and that reduction of sleep disturbances will result in a reduction of daytime fatigue and somnolence. 28 candidates with perennial allergic rhinitis will be selected for participation. They must have subjective findings of nasal obstruction and of sleep disturbances with associated daytime fatigue. This study will be a cross-over, double-blinded placebo controlled study over eight weeks. Each participant will begin the active phase of the study for four weeks with a crossover to the alternative arm of the study for four weeks. Procedures include a medical history, complete physical exam, rhinitis severity questionnaire, prick allergy skin testing, scale for sleep disfunction (Hoddes 1978) and daily diary for sleep, daytime fatigue and nasal symptoms.