NASAL ANTIHISTAMINES & ALLERGIC RHINITIS INDUCED SLEEP DISTURBANCES

变应性鼻炎的主要表现之一是充血。鼻塞可使个体易患睡眠呼吸暂停和微觉醒。这种睡眠障碍会导致白天嗜睡和疲劳。鼻类固醇的使用在客观上和主观上都能有效地减少鼻塞。目前，还没有研究表明鼻腔类固醇能客观地降低鼻腔阻力、睡眠唤醒和白天疲劳。本研究的主要目的是证明鼻腔类固醇可以减少充血，从而减少睡眠障碍，减少睡眠障碍将减少白天的疲劳和嗜睡。共有28名常年性变应性鼻炎患者入选。他们必须有鼻塞和伴有白天疲劳的睡眠障碍的主观发现。这项研究将是一项为期八周的交叉、双盲安慰剂对照研究。每位参与者将开始为期四周的研究的积极阶段，并转入为期四周的研究的替代组。程序包括病史、完整的体检、鼻炎严重程度问卷、刺痛过敏皮肤试验、睡眠障碍量表（Hoddes 1978）和睡眠、日间疲劳和鼻症状的每日日记。

One of the main manifestations of allergic rhinitis is congestion. Nasal congestion can predispose the individual to sleep apnea and microarousals. This sleep disturbance can result in daytime somnolence and fatigue. The use of nasal steroids has been effective at reducing congestion, both objectively and subjectively. Presently, no study is available that shows objective decrease in nasal resistance, sleep arousals, and daytime fatigue in association with nasal steroids. The key objectives of this study are to demonstrate that nasal steroids can decrease congestion resulting in less sleep disturbances and that reduction of sleep disturbances will result in a reduction of daytime fatigue and somnolence. 28 candidates with perennial allergic rhinitis will be selected for participation. They must have subjective findings of nasal obstruction and of sleep disturbances with associated daytime fatigue. This study will be a cross-over, double-blinded placebo controlled study over eight weeks. Each participant will begin the active phase of the study for four weeks with a crossover to the alternative arm of the study for four weeks. Procedures include a medical history, complete physical exam, rhinitis severity questionnaire, prick allergy skin testing, scale for sleep disfunction (Hoddes 1978) and daily diary for sleep, daytime fatigue and nasal symptoms.