BRAIN STEM MECHANISMS CONTROLLING RHYTHMICAL JAW MOVEMEN

这项建议的具体目的是阐明脑干神经元 负责自发生产和协调的机制 发生和皮质诱导的节律性下颌运动（RJM），类似于 豚鼠的咀嚼 我们建议有系统地搜索 脑干网状结构的神经元的网站，参与 生产RJM。 本建议分为三个主要部分。 第一部分将利用脑干微刺激技术和场 三叉神经特定运动神经元池内的潜在分析 运动核，以确定特定的脑干部位是否对 车辆调配场 第二部分将涉及细胞外记录， 脑干的网状神经元。 计算机分析和 将采用尖峰触发平均技术来确定 存在于脑干神经元之间的功能连接， 运动神经元和咀嚼区的皮质。 最后，细胞内 记录来自特定的三叉神经运动神经元， 肌肉控制打开，关闭和横向运动的 将在脑干部位的微刺激期间获得下颌骨， 影响三叉神经运动核 这将使我们能够确定 这些区域对特定运动神经元的精确突触作用。 这项研究的长期目标是了解中枢神经系统是如何 系统启动，协调，并执行有节奏的刻板印象 咀嚼时下颌骨的运动。 无意识的，有节奏的 人类在睡眠期间发生颌的运动（磨牙症）。 这些 患者往往会出现肌面疼痛。 不受控制的节律性运动 口面部结构的损伤也发生在长期给药期间， 停用抗精神病药物（迟发性运动障碍）。 的病因 这些运动障碍是未知的。 这些研究的结果将 阐明了负责这些不自主的神经机制， 有节奏的下颌运动

The specific aim of this proposal is to elucidate the brain stem neuronal mechanisms responsible for the production and coordination of spontaneously occurring and cortically induced rhythmical jaw movements (RJM) resembling mastication in the guinea pig. We propose to systematically search the brain stem reticular formation for neuronal sites which participate in the production of RJMs. This proposal is divided into three main sections. Part one will utilize brain stem microstimulation techniques and field potential analysis within specific motoneuronal pools of the trigeminal motor nucleus to determine if a particular brain stem site has an effect on the motor pool. Part two will involve extracellular recording from reticular neurons of the brain stem during RJMs. Computer analysis and spike triggered averaging techniques will be employed to determine the functional connectivity that exists between the brain stem neuron, motoneuron and masticatory area of the cortex. Finally, intracellular recording from specific identified trigeminal motoneurons innervating the muscles which control opening, closing and lateral movements of the mandible will be obtained during microstimulation of brain stem sites shown to effect the trigeminal motor nucleus. This will allow us to determine the precise synaptic effect these areas exert on the specific motoneurons. The long term goal of the research is to understand how the central nervous system initiates, coordinates, and executes the rhythmical stereotypic movements of the mandible during mastication. Involuntary, rhythmical movements of the jaws occurs in humans during sleep (bruxism). These patients tend to develop myofacial pain. Uncontrolled rhythmical movements of oral-facial structures also occurs during long term administration and withdrawal from anti-psycotic drugs (tardive dyskinesia). The etiology of these movement disorders is unknown. The results of these studies will shed light on the neuronal mechanism(s) responsible for these involuntary rhythmical jaw movements.