BRAIN STEM MECHANISMS CONTROLLING RHYTHMICAL JAW MOVEMEN

这项建议的具体目的是阐明脑干神经元 负责自发生产和协调的机制 发生和皮质诱导的节律性下颌运动(RJM)，类似于 豚鼠的咀嚼。我们建议系统地搜索 脑干网状结构的神经元部位参与 生产RJM。这项提案分为三个主要部分。 第一部分将利用脑干微刺激技术和领域 三叉神经特定运动神经元池内的电位分析 运动核来确定特定的脑干部位是否对 汽车共用车。第二部分将涉及细胞外记录 RJMS期间脑干的网状神经元。计算机分析和 将采用尖峰触发的平均技术来确定 存在于脑干神经元之间的功能连接， 皮质的运动神经元和咀嚼区。最后，细胞内 从支配三叉神经运动神经元的特定三叉神经神经元记录 控制关节的打开、闭合和侧向运动的肌肉 在微刺激脑干部位的过程中将获得下颌骨 影响三叉神经运动核。这将使我们能够确定 这些区域对特定运动神经元施加的精确突触效应。 这项研究的长期目标是了解中枢神经是如何 系统启动、协调和执行有节奏的刻板印象 咀嚼过程中下颌骨的移动。无意识的，有节奏的 人类在睡眠时会发生颌骨的运动(磨牙症)。这些 患者往往会出现肌肉面部疼痛。不受控制的有节奏的动作 在长期服药期间也会发生口腔-面部结构的改变 停用抗精神病药物(迟发性运动障碍)。该病的病因学 这些运动障碍是未知的。这些研究的结果将 阐明了导致这些非自愿行为的神经机制(S) 有节奏的下巴运动。

The specific aim of this proposal is to elucidate the brain stem neuronal mechanisms responsible for the production and coordination of spontaneously occurring and cortically induced rhythmical jaw movements (RJM) resembling mastication in the guinea pig. We propose to systematically search the brain stem reticular formation for neuronal sites which participate in the production of RJMs. This proposal is divided into three main sections. Part one will utilize brain stem microstimulation techniques and field potential analysis within specific motoneuronal pools of the trigeminal motor nucleus to determine if a particular brain stem site has an effect on the motor pool. Part two will involve extracellular recording from reticular neurons of the brain stem during RJMs. Computer analysis and spike triggered averaging techniques will be employed to determine the functional connectivity that exists between the brain stem neuron, motoneuron and masticatory area of the cortex. Finally, intracellular recording from specific identified trigeminal motoneurons innervating the muscles which control opening, closing and lateral movements of the mandible will be obtained during microstimulation of brain stem sites shown to effect the trigeminal motor nucleus. This will allow us to determine the precise synaptic effect these areas exert on the specific motoneurons. The long term goal of the research is to understand how the central nervous system initiates, coordinates, and executes the rhythmical stereotypic movements of the mandible during mastication. Involuntary, rhythmical movements of the jaws occurs in humans during sleep (bruxism). These patients tend to develop myofacial pain. Uncontrolled rhythmical movements of oral-facial structures also occurs during long term administration and withdrawal from anti-psycotic drugs (tardive dyskinesia). The etiology of these movement disorders is unknown. The results of these studies will shed light on the neuronal mechanism(s) responsible for these involuntary rhythmical jaw movements.