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Talking to the Clock: Understanding How The Molecular Circadian Clock Is Regulated By The Cellular Environment

与时钟对话：了解分子昼夜节律钟如何受细胞环境调节

基本信息

批准号：
BB/N01992X/1
负责人：
Aarti Jagannath
金额：
$ 128.9万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FN01992X%2F1
关键词：
Talking Clock Understanding How Molecular

项目摘要

All organisms display daily rhythms in physiology and behaviour, such as the sleep-wake cycle, but also including rhythms in blood pressure, body temperature and cognitive ability. These rhythms are driven by a circadian (circa-around, diem-day) clock that is a molecular pacemaker occurring in most cells throughout the body. In order for this clock to serve its purpose, it must be synchronized to external environmental cues, such as the timing of the day-night cycle and availability of food.Our understanding of how this clock is set to the correct time is very basic. I propose to use cellular models of the clock to understand how external factors both within and external to the cellular environment relay information to the molecular clock and how this information is integrated. We are now realising that disrupted circadian rhythms can lead to a wide range of conditions that impact quality of life and healthy ageing, such as diabetes and mental illness and that the circadian clock represents a novel and untapped target for these conditions. My research will provide new avenues by which the clock can be targeted for therapeutic purposes.This work will be undertaken at the Sleep and Circadian Neuroscience Institute at the University of Oxford in collaboration with the Departments of Pharmacology at Oxford, the University of Geneva, F. Hoffman-La Roche, Basel and Axolabs GmBH, Germany.

所有生物体都显示出生理和行为的每日节律，例如睡眠-觉醒周期，但也包括血压，体温和认知能力的节律。这些节奏是由昼夜节律（昼夜）时钟驱动的，这是一种分子起搏器，发生在全身大多数细胞中。为了使这个时钟发挥作用，它必须与外部环境线索同步，例如昼夜循环的时间和食物的可用性。我们对这个时钟如何设置为正确时间的理解是非常基本的。我建议使用细胞模型的时钟，以了解如何内外的细胞环境的外部因素中继信息的分子钟，以及如何将这些信息整合。我们现在意识到，昼夜节律紊乱会导致一系列影响生活质量和健康老龄化的疾病，如糖尿病和精神疾病，而生物钟是这些疾病的一个新的和未开发的目标。我的研究将为生物钟的治疗目的提供新的途径。这项工作将在牛津大学睡眠和昼夜神经科学研究所与牛津大学药理学系、日内瓦大学、F。Hoffman-La Roche，巴塞尔和Axolabs GmBH，德国。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Melanopsin: photoreceptors, physiology and potential

黑视蛋白：光感受器、生理学和潜力

DOI：
10.1016/j.cophys.2018.08.001
发表时间：
2018
期刊：
Current Opinion in Physiology
影响因子：
2.5
作者：
Palumaa T
通讯作者：
Palumaa T

The multiple roles of salt-inducible kinases in regulating physiology.

盐诱导激酶在调节生理学中的多重作用。

DOI：
10.1152/physrev.00023.2022
发表时间：
2023-07-01
期刊：
PHYSIOLOGICAL REVIEWS
影响因子：
33.6
作者：
Jagannath, Aarti;Taylor, Lewis;Ru, Yining;Wakaf, Zeinab;Akpobaro, Kayomavua;Vasudevan, Sridhar;Foster, Russell G.
通讯作者：
Foster, Russell G.

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

DOI：
10.1038/s41467-021-22179-z
发表时间：
2021-04-09
期刊：
Nature communications
影响因子：
16.6
作者：
Jagannath A;Varga N;Dallmann R;Rando G;Gosselin P;Ebrahimjee F;Taylor L;Mosneagu D;Stefaniak J;Walsh S;Palumaa T;Di Pretoro S;Sanghani H;Wakaf Z;Churchill GC;Galione A;Peirson SN;Boison D;Brown SA;Foster RG;Vasudevan SR
通讯作者：
Vasudevan SR

The genetics of circadian rhythms, sleep and health.