Improved conjugate vaccines derived from a bacterial immunomodulatory protein

源自细菌免疫调节蛋白的改良结合疫苗

• 批准号: BB/N022165/1
• 负责人: Jean Van Den Elsen
• 金额: $ 24.35万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN022165%2F1
• 关键词: Improved; conjugate; vaccines; derived; bacterial

TB remains a major health and economic burden. Key discoveries (University of Bath) and initial vaccination studies (Newcastle University) have established that a bacterial protein known as Sbi (from Staphylococcus aureus) can improve immune responses to a TB fragment. What makes our Sbi pro-vaccines an attractive commercial opportunity is our findings that Sbi can locally activate the innate immune system of all mammals tested to date. As such, vaccines developed using Sbi could be used across multiple species, including cattle and humans. Here, we will establish how successful Sbi conjugates/compounds are at generating an appropriate adaptive immune response against TB. These studies will lead to full TB challenge experiments in the future, which will allow us to confirm Sbi conjugates as highly effective multifunctional vaccines for animals; providing a clear pathway to commercialization of novel Sbi conjugate based vaccines to improve animal health and world food security.

结核病仍然是一个主要的健康和经济负担。关键发现（巴斯大学）和初步疫苗接种研究（纽卡斯尔大学）已经确定，一种被称为Sbi的细菌蛋白（来自金黄色葡萄球菌）可以提高对结核病片段的免疫反应。使我们的Sbi前疫苗成为一个有吸引力的商业机会的是我们的发现，Sbi可以局部激活迄今为止测试的所有哺乳动物的先天免疫系统。因此，使用Sbi开发的疫苗可以用于多个物种，包括牛和人类。 在此，我们将确定Sbi缀合物/化合物在产生针对TB的适当适应性免疫应答方面的成功程度。这些研究将在未来进行全面的结核病挑战实验，这将使我们能够确认Sbi缀合物是高效的动物多功能疫苗;为新型Sbi缀合物疫苗的商业化提供了一条明确的途径，以改善动物健康和世界粮食安全。

项目成果

A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.

• DOI: 10.1016/j.imbio.2017.10.002
• 发表时间: 2018-01
• 期刊: Immunobiology
• 影响因子: 2.8
• 作者: He YG;Pappworth IY;Rossbach A;Paulin J;Mavimba T;Hayes C;Kulik L;Holers VM;Knight AM;Marchbank KJ
• 通讯作者: Marchbank KJ

Insights into the role of C3d dimers in B cell activation and Staphylococcal immune evasion

深入了解 C3d 二聚体在 B 细胞激活和葡萄球菌免疫逃避中的作用

• DOI: 10.1101/2020.04.22.054700
• 发表时间: 2020
• 作者: Wahid A

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.

• DOI: 10.3389/fimmu.2021.714055
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Wahid AA;Dunphy RW;Macpherson A;Gibson BG;Kulik L;Whale K;Back C;Hallam TM;Alkhawaja B;Martin RL;Meschede I;Laabei M;Lawson ADG;Holers VM;Watts AG;Crennell SJ;Harris CL;Marchbank KJ;van den Elsen JMH
• 通讯作者: van den Elsen JMH

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

利用葡萄球菌免疫逃避蛋白Sbi作为新型疫苗佐剂

• DOI: 10.3204/pubdb-2019-05104
• 发表时间: 2019
• 作者: Yang Y

Utilisation of staphylococcal immune evasion protein Sbi as a novel vaccine adjuvant

葡萄球菌免疫逃避蛋白Sbi作为新型疫苗佐剂的应用

• DOI: 10.1101/413294
• 发表时间: 2018
• 作者: Yang Y