ANIHWA call 3: ARBONET Epidemiological models for control of arboviral disease for Europe

ANIHWA 号召 3：欧洲控制虫媒病毒病的 ARBONET 流行病学模型

• 批准号: BB/N023889/2
• 负责人: Lesley Bell-Sakyi
• 金额: $ 26.44万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN023889%2F2
• 关键词: ANIHWA; call; ARBONET; Epidemiological; models

Emerging and re-emerging infectious viral diseases continue to challenge both animal and human health around the world. For Europe, vector-borne infections, such as mosquito-borne West Nile fever (WNF), and Rift Valley fever (RVF) and tick-borne Crimean-Congo hemorrhagic fever (CCHF), pose a continuous risk of incursions or northward expansion from endemic areas. The drivers of these infections are multifactorial and include increased mobility of human populations, increased global trade in live animals and foodstuffs, and climate change affecting the geographic distribution and competence of vectors. In addition, persistent arbovirus infections in wildlife pose unprecedented challenges to formulation of proper surveillance and control actions, due to the complexity of the interfaces between different host populations.The proposed initiative "ARBONET" will be focused on WNF, CCHF and RVF infections, specifically on development of epidemiological models that can inform risk-based surveillance and interventions that can control disease outbreaks in Europe. The major goal of this joint initiative is to create a multidisciplinary research network combining the expertise of veterinary and human epidemiologists, disease modellers, virologists and arthropod biologists to increase knowledge and understanding that will facilitate rapid control of disease outbreaks. The ARBONET proposal has the following specific objectives: 1) to develop epidemiological models of possible scenarios of CCHF, RVF and WNF spread in Europe, evaluating possible risk-based surveillance approaches and control strategies, 2) to promote epidemiological studies on distribution of viral genetic subpopulations, 3) to increase the knowledge of virus-vector and virus-vertebrate host interactions, and 4) to support dissemination of knowledge on the epidemiology, surveillance and control of these diseases.

新出现和再次出现的传染性病毒疾病继续对世界各地的动物和人类健康构成挑战。在欧洲，媒介传播的感染，如蚊媒传播的西尼罗热(WNF)、裂谷热(RVF)和壁虱传播的克里米亚-刚果出血热(CCHF)，构成了从流行区入侵或向北传播的持续风险。这些感染的驱动因素是多方面的，包括人口流动性增加、活动物和食品全球贸易增加以及气候变化影响病媒的地理分布和能力。此外，由于不同宿主种群之间界面的复杂性，野生动物中持续的虫媒病毒感染对制定适当的监测和控制行动构成了前所未有的挑战。拟议的“ArboNET”倡议将侧重于WNF、CCHF和RVF感染，特别是开发流行病学模型，为基于风险的监测和干预措施提供信息，从而控制欧洲的疾病暴发。这一联合倡议的主要目标是创建一个多学科研究网络，将兽医和人类流行病学家、疾病建模专家、病毒学家和节肢动物生物学家的专业知识结合起来，以增加知识和了解，从而促进疾病暴发的快速控制。ArboNET的建议有以下具体目标：1)开发CCHF、RVF和WNF在欧洲传播的可能情景的流行病学模型，评估可能的基于风险的监测方法和控制战略，2)促进关于病毒遗传亚群分布的流行病学研究，3)增加关于病毒-媒介和病毒-脊椎动物宿主相互作用的知识，以及4)支持传播关于这些疾病的流行病学、监测和控制的知识。

项目成果

Virus-Derived DNA Forms Mediate the Persistent Infection of Tick Cells by Hazara Virus and Crimean-Congo Hemorrhagic Fever Virus.

病毒衍生的 DNA 形式介导哈扎拉病毒和克里米亚-刚果出血热病毒对蜱细胞的持续感染。

• DOI: 10.1128/jvi.01638-21
• 发表时间: 2021
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Salvati MV

Bacterial Pathogens and Symbionts Harboured by Ixodes ricinus Ticks Parasitising Red Squirrels in the United Kingdom.

• DOI: 10.3390/pathogens10040458
• 发表时间: 2021-04-11
• 期刊: Pathogens (Basel, Switzerland)
• 作者: Luu L;Palomar AM;Farrington G;Schilling AK;Premchand-Branker S;McGarry J;Makepeace BL;Meredith A;Bell-Sakyi L
• 通讯作者: Bell-Sakyi L

Isolation of Candidatus Rickettsia vini from Belgian Ixodes arboricola ticks and propagation in tick cell lines.

• DOI: 10.1016/j.ttbdis.2020.101511
• 发表时间: 2020-11
• 期刊: Ticks and tick-borne diseases
• 影响因子: 3.2
• 作者: Al-Khafaji AM;Bell-Sakyi L;Fracasso G;Luu L;Heylen D;Matthysen E;Oteo JA;Palomar AM
• 通讯作者: Palomar AM

Isolation and partial characterisation of a novel Trypanosoma from the tick Ixodes ricinus.

从蓖麻硬蜱中分离和部分表征新型锥虫。

• DOI: 10.1016/j.ttbdis.2020.101501
• 发表时间: 2020
• 期刊: Ticks and tick-borne diseases
• 影响因子: 3.2
• 作者: Luu L