INITIAL LESION OF ADULT PERIODONTITIS

这项提议的长期目标是检测和 牙周初始病变的微生物学特征。当前 关于这类受试者疾病活动率的信息很少。 这项调查比较了临床和微生物学 成人牙周炎的首发病变特点 牙周炎与健康。临床、微生物和免疫学特征 将寻求区分渐进性依恋丧失， 牙周炎，和健康。 第一个目标将确定最初的临床特征 成人牙周病变。健康和牙周炎的受试者将 使用电子温度和附件进行纵向监控 水平探头寻找牙周明显丢失的部位 依恋程度(疾病活动性)。牙周炎的人口将是 通过筛查升高的受试者来丰富活性部位 牙龈下的温度。慢性阻塞性肺疾病的临床特点比较 有活动性损害的部位和受试者，有牙周炎部位来自 牙周炎患者和健康受试者的健康部位应 指出哪些特征与疾病活动有关，以及是否有 包括体温升高在内的临床特征是 疾病活动的风险增加。 为了确定最初牙周病变的病因， 主要可培养微生物区系将根据疾病活动性确定 并与牙周炎的牙周炎部位进行比较。 受试者，以及健康受试者中的健康部位。两个版本的比较 有牙周炎的活动性病变和健康部位的微生物区系应 指出哪些物种与进行性疾病有关，以及 任何微生物都是转化为二氧化碳的风险的有用指标 健康或牙周炎到活动性疾病。将寻求血清抗体 对优势菌种进行免疫学鉴定 最初的牙周病变。 最终，这些信息将有助于及早识别 患牙周炎风险高的受试者，并改善我们的 对牙周病初期的认识。

The long term objective of this proposal is to detect and microbiologically characterize the initial periodontal lesion. Current information on the rate of disease activity in such subjects is minimal. This investigation compares the clinical and microbiological characteristics of the initial lesion of adult periodontitis, with gingivitis and health. Clinical, microbial and immunologic features will be sought that discriminate between progressive attachment loss, gingivitis, and health. The first aim will determine clinical features of the initial periodontal lesion in adults. Healthy and gingivitis subjects will be monitored longitudinally using electronic temperature and attachment level probes seeking sites showing significant losses in periodontal attachment level (disease activity). The gingivitis population will be enriched for active sites by screening for subjects with elevated subgingival temperatures. Comparison of clinical characteristics of sites and subjects with active lesions, with gingivitis sites from gingivitis subjects, and healthy sites from healthy subjects, should indicate which features are related to disease activity, and whether any clinical features including increased temperature are indicators for elevated risk for disease activity. To determine the etiology of the initial periodontal lesion, the predominant cultivable microbiota will be determined from disease active sites, and compared with that of gingivitis sites in gingivitis subjects, and with healthy sites in healthy subjects. Comparison of the microbiota of active lesions with gingivitis and healthy sites should indicate which species are related to progressive disease, and whether any microorganisms are useful indicators of the risk for conversion of health or gingivitis to active disease. Serum antibodies will be sought to dominant subgingival species to immunologically characterize the initial periodontal lesion. Ultimately, this information will contribute to early identification of subjects at elevated risk for onset of periodontitis, and improve our understanding of the initial stage of periodontal disease.