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JUVENILE DIABETES MELLITUS EPIDEMIOLOGY & ETIOLOGY

JUVENILE DIABETES MELLITUS EPIDEMIOLOGY & ETIOLOGY
青少年糖尿病流行病学
批准号：
3227252
负责人：
ALLAN L DRASH
金额：
$58.22万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-09-15 至 1993-11-30
来源：
https://reporter.nih.gov/project-details/3227252
关键词：
autoimmune disorder blood chemistry blood glucose blood group antigens case history diabetes mellitus genetics disease /disorder classification disease /disorder proneness /risk epidemiology family genetic markers genetic registry /resource /referral center genome human age group human genetic material tag human population genetics human subject immunogenetics immunoglobulins insulin dependent diabetes mellitus linkage mapping longitudinal human study metabolism disorder diagnosis patient /disease registry transposon /insertion element virus DNA virus related diabetes mellitus

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中文摘要
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英文摘要
The proposed research will evaluate the immunologic and environmental determinants of the risk of insulin dependent diabetes mellitus (IDDM). Specifically, we will: 1. Monitor the incidence of IDDM in Allegheny County, PA, over 25 years (1965-1990) as well as the world. 2. Assess the associations between specific serologic and molecular markers to the risk of IDDM in 90 multiple sibling families, 58 affected parent offspring families, and 60 single case families. 3. Evaluate the association between viral DNA insertion into the human genome and IDDM. 4. Continue to collect samples on first degree relatives of cases prior to conversion to IDDM.
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会议论文
ETIOLOGY AND EPIDEMIOLOGY OF INSULIN DEPENDENT DIABETES MELLITUS
RESEARCH TRAINING IN PEDIATRIC ENDOCRINOLOGY & DIABETES
DIABETES CONTROL AND COMPLICATIONS TRIAL
DIABETES CONTROL AND COMPLICATIONS TRIAL
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